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SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage

Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for...

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Autores principales: Karami Fath, Mohsen, Jahangiri, Abolfazl, Ganji, Mahmoud, Sefid, Fatemeh, Payandeh, Zahra, Hashemi, Zahra Sadat, Pourzardosht, Navid, Hessami, Anahita, Mard-Soltani, Maysam, Zakeri, Alireza, Rahbar, Mohammad Reza, Khalili, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383889/
https://www.ncbi.nlm.nih.gov/pubmed/34447375
http://dx.doi.org/10.3389/fimmu.2021.705772
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author Karami Fath, Mohsen
Jahangiri, Abolfazl
Ganji, Mahmoud
Sefid, Fatemeh
Payandeh, Zahra
Hashemi, Zahra Sadat
Pourzardosht, Navid
Hessami, Anahita
Mard-Soltani, Maysam
Zakeri, Alireza
Rahbar, Mohammad Reza
Khalili, Saeed
author_facet Karami Fath, Mohsen
Jahangiri, Abolfazl
Ganji, Mahmoud
Sefid, Fatemeh
Payandeh, Zahra
Hashemi, Zahra Sadat
Pourzardosht, Navid
Hessami, Anahita
Mard-Soltani, Maysam
Zakeri, Alireza
Rahbar, Mohammad Reza
Khalili, Saeed
author_sort Karami Fath, Mohsen
collection PubMed
description Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*08:01, HLA-A*024:02, HLA-A*11:01 and HLA-B*27:05. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development.
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spelling pubmed-83838892021-08-25 SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage Karami Fath, Mohsen Jahangiri, Abolfazl Ganji, Mahmoud Sefid, Fatemeh Payandeh, Zahra Hashemi, Zahra Sadat Pourzardosht, Navid Hessami, Anahita Mard-Soltani, Maysam Zakeri, Alireza Rahbar, Mohammad Reza Khalili, Saeed Front Immunol Immunology Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*08:01, HLA-A*024:02, HLA-A*11:01 and HLA-B*27:05. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development. Frontiers Media S.A. 2021-08-10 /pmc/articles/PMC8383889/ /pubmed/34447375 http://dx.doi.org/10.3389/fimmu.2021.705772 Text en Copyright © 2021 Karami Fath, Jahangiri, Ganji, Sefid, Payandeh, Hashemi, Pourzardosht, Hessami, Mard-Soltani, Zakeri, Rahbar and Khalili https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Karami Fath, Mohsen
Jahangiri, Abolfazl
Ganji, Mahmoud
Sefid, Fatemeh
Payandeh, Zahra
Hashemi, Zahra Sadat
Pourzardosht, Navid
Hessami, Anahita
Mard-Soltani, Maysam
Zakeri, Alireza
Rahbar, Mohammad Reza
Khalili, Saeed
SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title_full SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title_fullStr SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title_full_unstemmed SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title_short SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
title_sort sars-cov-2 proteome harbors peptides which are able to trigger autoimmunity responses: implications for infection, vaccination, and population coverage
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383889/
https://www.ncbi.nlm.nih.gov/pubmed/34447375
http://dx.doi.org/10.3389/fimmu.2021.705772
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