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SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage
Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383889/ https://www.ncbi.nlm.nih.gov/pubmed/34447375 http://dx.doi.org/10.3389/fimmu.2021.705772 |
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author | Karami Fath, Mohsen Jahangiri, Abolfazl Ganji, Mahmoud Sefid, Fatemeh Payandeh, Zahra Hashemi, Zahra Sadat Pourzardosht, Navid Hessami, Anahita Mard-Soltani, Maysam Zakeri, Alireza Rahbar, Mohammad Reza Khalili, Saeed |
author_facet | Karami Fath, Mohsen Jahangiri, Abolfazl Ganji, Mahmoud Sefid, Fatemeh Payandeh, Zahra Hashemi, Zahra Sadat Pourzardosht, Navid Hessami, Anahita Mard-Soltani, Maysam Zakeri, Alireza Rahbar, Mohammad Reza Khalili, Saeed |
author_sort | Karami Fath, Mohsen |
collection | PubMed |
description | Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*08:01, HLA-A*024:02, HLA-A*11:01 and HLA-B*27:05. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development. |
format | Online Article Text |
id | pubmed-8383889 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-83838892021-08-25 SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage Karami Fath, Mohsen Jahangiri, Abolfazl Ganji, Mahmoud Sefid, Fatemeh Payandeh, Zahra Hashemi, Zahra Sadat Pourzardosht, Navid Hessami, Anahita Mard-Soltani, Maysam Zakeri, Alireza Rahbar, Mohammad Reza Khalili, Saeed Front Immunol Immunology Autoimmune diseases (ADs) could occur due to infectious diseases and vaccination programs. Since millions of people are expected to be infected with SARS-CoV-2 and vaccinated against it, autoimmune consequences seem inevitable. Therefore, we have investigated the whole proteome of the SARS-CoV-2 for its ability to trigger ADs. In this regard, the entire proteome of the SARS-CoV-2 was chopped into more than 48000 peptides. The produced peptides were searched against the entire human proteome to find shared peptides with similar experimentally confirmed T-cell and B-cell epitopes. The obtained peptides were checked for their ability to bind to HLA molecules. The possible population coverage was calculated for the most potent peptides. The obtained results indicated that the SARS-CoV-2 and human proteomes share 23 peptides originated from ORF1ab polyprotein, nonstructural protein NS7a, Surface glycoprotein, and Envelope protein of SARS-CoV-2. Among these peptides, 21 peptides had experimentally confirmed equivalent epitopes. Amongst, only nine peptides were predicted to bind to HLAs with known global allele frequency data, and three peptides were able to bind to experimentally confirmed HLAs of equivalent epitopes. Given the HLAs which have already been reported to be associated with ADs, the ESGLKTIL, RYPANSIV, NVAITRAK, and RRARSVAS were determined to be the most harmful peptides of the SARS-CoV-2 proteome. It would be expected that the COVID-19 pandemic and the vaccination against this pathogen could significantly increase the ADs incidences, especially in populations harboring HLA-B*08:01, HLA-A*024:02, HLA-A*11:01 and HLA-B*27:05. The Southeast Asia, East Asia, and Oceania are at higher risk of AD development. Frontiers Media S.A. 2021-08-10 /pmc/articles/PMC8383889/ /pubmed/34447375 http://dx.doi.org/10.3389/fimmu.2021.705772 Text en Copyright © 2021 Karami Fath, Jahangiri, Ganji, Sefid, Payandeh, Hashemi, Pourzardosht, Hessami, Mard-Soltani, Zakeri, Rahbar and Khalili https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Karami Fath, Mohsen Jahangiri, Abolfazl Ganji, Mahmoud Sefid, Fatemeh Payandeh, Zahra Hashemi, Zahra Sadat Pourzardosht, Navid Hessami, Anahita Mard-Soltani, Maysam Zakeri, Alireza Rahbar, Mohammad Reza Khalili, Saeed SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title | SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title_full | SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title_fullStr | SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title_full_unstemmed | SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title_short | SARS-CoV-2 Proteome Harbors Peptides Which Are Able to Trigger Autoimmunity Responses: Implications for Infection, Vaccination, and Population Coverage |
title_sort | sars-cov-2 proteome harbors peptides which are able to trigger autoimmunity responses: implications for infection, vaccination, and population coverage |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8383889/ https://www.ncbi.nlm.nih.gov/pubmed/34447375 http://dx.doi.org/10.3389/fimmu.2021.705772 |
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