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Are suspensory ligaments important for middle ear reconstruction?

As the resolution of 3D printing techniques improves, the possibility of individualized, 3-ossicle constructions adds a new dimension to middle ear prostheses. In order to optimize these designs, it is essential to understand how the ossicles and ligaments work together to transmit sound, and thus h...

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Autores principales: Brister, Eileen Y., Withnell, Robert H., Shevchenko, Pavel, Richter, Claus-Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384183/
https://www.ncbi.nlm.nih.gov/pubmed/34428235
http://dx.doi.org/10.1371/journal.pone.0255821
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author Brister, Eileen Y.
Withnell, Robert H.
Shevchenko, Pavel
Richter, Claus-Peter
author_facet Brister, Eileen Y.
Withnell, Robert H.
Shevchenko, Pavel
Richter, Claus-Peter
author_sort Brister, Eileen Y.
collection PubMed
description As the resolution of 3D printing techniques improves, the possibility of individualized, 3-ossicle constructions adds a new dimension to middle ear prostheses. In order to optimize these designs, it is essential to understand how the ossicles and ligaments work together to transmit sound, and thus how ligaments should be replicated in a middle ear reconstruction. The middle ear ligaments are thought to play a significant role in maintaining the position of the ossicles and constraining axis of rotation. Paradoxically, investigations of the role of ligaments to date have shown very little impact on middle ear sound transmission. We explored the role of the two attachments in the gerbil middle ear analogous to human ligaments, the posterior incudal ligament and the anterior mallear process, severing both attachments and measuring change in hearing sensitivity. The impact of severing the attachments on the position of the ossicular chain was visualized using synchrotron microtomography imaging of the middle ear. In contrast to previous studies, a threshold change on the order of 20 dB across a wide range of frequencies was found when both ligaments were severed. Concomitantly, a shift in position of the ossicles was observed from the x-ray imaging and 3D renderings of the ossicular chain. These findings contrast with previous studies, demonstrating that these ligaments play a significant role in the transmission of sound through the middle ear. It appears that both mallear and incudal ligaments must be severed in order to impair sound transmission. The results of this study have significance for middle ear reconstructive surgery and the design of 3D-printed three-ossicle biocompatible prostheses.
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spelling pubmed-83841832021-08-25 Are suspensory ligaments important for middle ear reconstruction? Brister, Eileen Y. Withnell, Robert H. Shevchenko, Pavel Richter, Claus-Peter PLoS One Research Article As the resolution of 3D printing techniques improves, the possibility of individualized, 3-ossicle constructions adds a new dimension to middle ear prostheses. In order to optimize these designs, it is essential to understand how the ossicles and ligaments work together to transmit sound, and thus how ligaments should be replicated in a middle ear reconstruction. The middle ear ligaments are thought to play a significant role in maintaining the position of the ossicles and constraining axis of rotation. Paradoxically, investigations of the role of ligaments to date have shown very little impact on middle ear sound transmission. We explored the role of the two attachments in the gerbil middle ear analogous to human ligaments, the posterior incudal ligament and the anterior mallear process, severing both attachments and measuring change in hearing sensitivity. The impact of severing the attachments on the position of the ossicular chain was visualized using synchrotron microtomography imaging of the middle ear. In contrast to previous studies, a threshold change on the order of 20 dB across a wide range of frequencies was found when both ligaments were severed. Concomitantly, a shift in position of the ossicles was observed from the x-ray imaging and 3D renderings of the ossicular chain. These findings contrast with previous studies, demonstrating that these ligaments play a significant role in the transmission of sound through the middle ear. It appears that both mallear and incudal ligaments must be severed in order to impair sound transmission. The results of this study have significance for middle ear reconstructive surgery and the design of 3D-printed three-ossicle biocompatible prostheses. Public Library of Science 2021-08-24 /pmc/articles/PMC8384183/ /pubmed/34428235 http://dx.doi.org/10.1371/journal.pone.0255821 Text en © 2021 Brister et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Brister, Eileen Y.
Withnell, Robert H.
Shevchenko, Pavel
Richter, Claus-Peter
Are suspensory ligaments important for middle ear reconstruction?
title Are suspensory ligaments important for middle ear reconstruction?
title_full Are suspensory ligaments important for middle ear reconstruction?
title_fullStr Are suspensory ligaments important for middle ear reconstruction?
title_full_unstemmed Are suspensory ligaments important for middle ear reconstruction?
title_short Are suspensory ligaments important for middle ear reconstruction?
title_sort are suspensory ligaments important for middle ear reconstruction?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384183/
https://www.ncbi.nlm.nih.gov/pubmed/34428235
http://dx.doi.org/10.1371/journal.pone.0255821
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