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Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?

Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharyn...

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Autores principales: Mendes-Correa, Maria C., Tozetto-Mendoza, Tania Regina, Freire, Wilton S., Paiao, Heuder G. O., Ferraz, Andrea B. C., Mamana, Ana C., Ferreira, Noely E., de Paula, Anderson V., Felix, Alvina C., Romano, Camila M., Braz-Silva, Paulo H., Leal, Fabio E., Grespan, Regina M. Z., Sabino, Ester C., Costa, Silvia F., Witkin, Steven S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384193/
https://www.ncbi.nlm.nih.gov/pubmed/34428230
http://dx.doi.org/10.1371/journal.pone.0256357
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author Mendes-Correa, Maria C.
Tozetto-Mendoza, Tania Regina
Freire, Wilton S.
Paiao, Heuder G. O.
Ferraz, Andrea B. C.
Mamana, Ana C.
Ferreira, Noely E.
de Paula, Anderson V.
Felix, Alvina C.
Romano, Camila M.
Braz-Silva, Paulo H.
Leal, Fabio E.
Grespan, Regina M. Z.
Sabino, Ester C.
Costa, Silvia F.
Witkin, Steven S.
author_facet Mendes-Correa, Maria C.
Tozetto-Mendoza, Tania Regina
Freire, Wilton S.
Paiao, Heuder G. O.
Ferraz, Andrea B. C.
Mamana, Ana C.
Ferreira, Noely E.
de Paula, Anderson V.
Felix, Alvina C.
Romano, Camila M.
Braz-Silva, Paulo H.
Leal, Fabio E.
Grespan, Regina M. Z.
Sabino, Ester C.
Costa, Silvia F.
Witkin, Steven S.
author_sort Mendes-Correa, Maria C.
collection PubMed
description Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharynx and could be a marker of COVID-19 status. Saliva from 91 individuals positive for SARS-CoV-2 in nasal-oropharyngeal samples, and from 126 individuals who were SARS-CoV-2-negative, all with mild respiratory symptoms, were analyzed. Both groups were similar in age, gender, symptom duration and time after symptom initiation when saliva was collected. Titers of TTV and SARS-CoV-2 were assessed by gene amplification. Loss of smell (p = 0.0001) and fever (p = 0.0186) were more prevalent in SARS-CoV-2-positive individuals, while sore throat (p = 0.0001), fatigue (p = 0.0037) and diarrhea (p = 0.0475) were more frequent in the SARS-CoV-2 negative group. The saliva TTV and nasal-oropharyngeal SARS-CoV-2 titers were correlated (p = 0.0085). The TTV level decreased as symptoms resolved in the SARS-CoV-2 infected group (p = 0.0285) but remained unchanged in the SARS-CoV-2 negative controls. In SARS-CoV-2 positive subjects who provided 2–4 saliva samples and in which TTV was initially present, the TTV titer always decreased over time as symptoms resolved. We propose that sequential TTV measurement in saliva is potentially useful to assess the likelihood of symptom resolution in SARS-CoV-2-positive individuals and to predict prognosis.
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spelling pubmed-83841932021-08-25 Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? Mendes-Correa, Maria C. Tozetto-Mendoza, Tania Regina Freire, Wilton S. Paiao, Heuder G. O. Ferraz, Andrea B. C. Mamana, Ana C. Ferreira, Noely E. de Paula, Anderson V. Felix, Alvina C. Romano, Camila M. Braz-Silva, Paulo H. Leal, Fabio E. Grespan, Regina M. Z. Sabino, Ester C. Costa, Silvia F. Witkin, Steven S. PLoS One Research Article Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharynx and could be a marker of COVID-19 status. Saliva from 91 individuals positive for SARS-CoV-2 in nasal-oropharyngeal samples, and from 126 individuals who were SARS-CoV-2-negative, all with mild respiratory symptoms, were analyzed. Both groups were similar in age, gender, symptom duration and time after symptom initiation when saliva was collected. Titers of TTV and SARS-CoV-2 were assessed by gene amplification. Loss of smell (p = 0.0001) and fever (p = 0.0186) were more prevalent in SARS-CoV-2-positive individuals, while sore throat (p = 0.0001), fatigue (p = 0.0037) and diarrhea (p = 0.0475) were more frequent in the SARS-CoV-2 negative group. The saliva TTV and nasal-oropharyngeal SARS-CoV-2 titers were correlated (p = 0.0085). The TTV level decreased as symptoms resolved in the SARS-CoV-2 infected group (p = 0.0285) but remained unchanged in the SARS-CoV-2 negative controls. In SARS-CoV-2 positive subjects who provided 2–4 saliva samples and in which TTV was initially present, the TTV titer always decreased over time as symptoms resolved. We propose that sequential TTV measurement in saliva is potentially useful to assess the likelihood of symptom resolution in SARS-CoV-2-positive individuals and to predict prognosis. Public Library of Science 2021-08-24 /pmc/articles/PMC8384193/ /pubmed/34428230 http://dx.doi.org/10.1371/journal.pone.0256357 Text en © 2021 Mendes-Correa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Mendes-Correa, Maria C.
Tozetto-Mendoza, Tania Regina
Freire, Wilton S.
Paiao, Heuder G. O.
Ferraz, Andrea B. C.
Mamana, Ana C.
Ferreira, Noely E.
de Paula, Anderson V.
Felix, Alvina C.
Romano, Camila M.
Braz-Silva, Paulo H.
Leal, Fabio E.
Grespan, Regina M. Z.
Sabino, Ester C.
Costa, Silvia F.
Witkin, Steven S.
Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title_full Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title_fullStr Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title_full_unstemmed Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title_short Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
title_sort torquetenovirus in saliva: a potential biomarker for sars-cov-2 infection?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384193/
https://www.ncbi.nlm.nih.gov/pubmed/34428230
http://dx.doi.org/10.1371/journal.pone.0256357
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