Cargando…
Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection?
Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharyn...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384193/ https://www.ncbi.nlm.nih.gov/pubmed/34428230 http://dx.doi.org/10.1371/journal.pone.0256357 |
_version_ | 1783741868308168704 |
---|---|
author | Mendes-Correa, Maria C. Tozetto-Mendoza, Tania Regina Freire, Wilton S. Paiao, Heuder G. O. Ferraz, Andrea B. C. Mamana, Ana C. Ferreira, Noely E. de Paula, Anderson V. Felix, Alvina C. Romano, Camila M. Braz-Silva, Paulo H. Leal, Fabio E. Grespan, Regina M. Z. Sabino, Ester C. Costa, Silvia F. Witkin, Steven S. |
author_facet | Mendes-Correa, Maria C. Tozetto-Mendoza, Tania Regina Freire, Wilton S. Paiao, Heuder G. O. Ferraz, Andrea B. C. Mamana, Ana C. Ferreira, Noely E. de Paula, Anderson V. Felix, Alvina C. Romano, Camila M. Braz-Silva, Paulo H. Leal, Fabio E. Grespan, Regina M. Z. Sabino, Ester C. Costa, Silvia F. Witkin, Steven S. |
author_sort | Mendes-Correa, Maria C. |
collection | PubMed |
description | Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharynx and could be a marker of COVID-19 status. Saliva from 91 individuals positive for SARS-CoV-2 in nasal-oropharyngeal samples, and from 126 individuals who were SARS-CoV-2-negative, all with mild respiratory symptoms, were analyzed. Both groups were similar in age, gender, symptom duration and time after symptom initiation when saliva was collected. Titers of TTV and SARS-CoV-2 were assessed by gene amplification. Loss of smell (p = 0.0001) and fever (p = 0.0186) were more prevalent in SARS-CoV-2-positive individuals, while sore throat (p = 0.0001), fatigue (p = 0.0037) and diarrhea (p = 0.0475) were more frequent in the SARS-CoV-2 negative group. The saliva TTV and nasal-oropharyngeal SARS-CoV-2 titers were correlated (p = 0.0085). The TTV level decreased as symptoms resolved in the SARS-CoV-2 infected group (p = 0.0285) but remained unchanged in the SARS-CoV-2 negative controls. In SARS-CoV-2 positive subjects who provided 2–4 saliva samples and in which TTV was initially present, the TTV titer always decreased over time as symptoms resolved. We propose that sequential TTV measurement in saliva is potentially useful to assess the likelihood of symptom resolution in SARS-CoV-2-positive individuals and to predict prognosis. |
format | Online Article Text |
id | pubmed-8384193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83841932021-08-25 Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? Mendes-Correa, Maria C. Tozetto-Mendoza, Tania Regina Freire, Wilton S. Paiao, Heuder G. O. Ferraz, Andrea B. C. Mamana, Ana C. Ferreira, Noely E. de Paula, Anderson V. Felix, Alvina C. Romano, Camila M. Braz-Silva, Paulo H. Leal, Fabio E. Grespan, Regina M. Z. Sabino, Ester C. Costa, Silvia F. Witkin, Steven S. PLoS One Research Article Torquetenovirus (TTV) is present in biological fluids from healthy individuals and measurement of its titer is used to assess immune status in individuals with chronic infections and after transplants. We assessed if the titer of TTV in saliva varied with the presence of SARS-CoV-2 in the nasopharynx and could be a marker of COVID-19 status. Saliva from 91 individuals positive for SARS-CoV-2 in nasal-oropharyngeal samples, and from 126 individuals who were SARS-CoV-2-negative, all with mild respiratory symptoms, were analyzed. Both groups were similar in age, gender, symptom duration and time after symptom initiation when saliva was collected. Titers of TTV and SARS-CoV-2 were assessed by gene amplification. Loss of smell (p = 0.0001) and fever (p = 0.0186) were more prevalent in SARS-CoV-2-positive individuals, while sore throat (p = 0.0001), fatigue (p = 0.0037) and diarrhea (p = 0.0475) were more frequent in the SARS-CoV-2 negative group. The saliva TTV and nasal-oropharyngeal SARS-CoV-2 titers were correlated (p = 0.0085). The TTV level decreased as symptoms resolved in the SARS-CoV-2 infected group (p = 0.0285) but remained unchanged in the SARS-CoV-2 negative controls. In SARS-CoV-2 positive subjects who provided 2–4 saliva samples and in which TTV was initially present, the TTV titer always decreased over time as symptoms resolved. We propose that sequential TTV measurement in saliva is potentially useful to assess the likelihood of symptom resolution in SARS-CoV-2-positive individuals and to predict prognosis. Public Library of Science 2021-08-24 /pmc/articles/PMC8384193/ /pubmed/34428230 http://dx.doi.org/10.1371/journal.pone.0256357 Text en © 2021 Mendes-Correa et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Mendes-Correa, Maria C. Tozetto-Mendoza, Tania Regina Freire, Wilton S. Paiao, Heuder G. O. Ferraz, Andrea B. C. Mamana, Ana C. Ferreira, Noely E. de Paula, Anderson V. Felix, Alvina C. Romano, Camila M. Braz-Silva, Paulo H. Leal, Fabio E. Grespan, Regina M. Z. Sabino, Ester C. Costa, Silvia F. Witkin, Steven S. Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title | Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title_full | Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title_fullStr | Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title_full_unstemmed | Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title_short | Torquetenovirus in saliva: A potential biomarker for SARS-CoV-2 infection? |
title_sort | torquetenovirus in saliva: a potential biomarker for sars-cov-2 infection? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384193/ https://www.ncbi.nlm.nih.gov/pubmed/34428230 http://dx.doi.org/10.1371/journal.pone.0256357 |
work_keys_str_mv | AT mendescorreamariac torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT tozettomendozataniaregina torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT freirewiltons torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT paiaoheudergo torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT ferrazandreabc torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT mamanaanac torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT ferreiranoelye torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT depaulaandersonv torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT felixalvinac torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT romanocamilam torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT brazsilvapauloh torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT lealfabioe torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT grespanreginamz torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT sabinoesterc torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT costasilviaf torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection AT witkinstevens torquetenovirusinsalivaapotentialbiomarkerforsarscov2infection |