Application of human liver organoids as a patient-derived primary model for HBV infection and related hepatocellular carcinoma

The molecular events that drive hepatitis B virus (HBV)-mediated transformation and tumorigenesis have remained largely unclear, due to the absence of a relevant primary model system. Here we propose the use of human liver organoids as a platform for modeling HBV infection and related tumorigenesis....

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Detalles Bibliográficos
Autores principales: De Crignis, Elisa, Hossain, Tanvir, Romal, Shahla, Carofiglio, Fabrizia, Moulos, Panagiotis, Khalid, Mir Mubashir, Rao, Shringar, Bazrafshan, Ameneh, Verstegen, Monique MA, Pourfarzad, Farzin, Koutsothanassis, Christina, Gehart, Helmuth, Kan, Tsung Wai, Palstra, Robert-Jan, Boucher, Charles, IJzermans, Jan NM, Huch, Meritxell, Boj, Sylvia F, Vries, Robert, Clevers, Hans, van der Laan, Luc JW, Hatzis, Pantelis, Mahmoudi, Tokameh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384419/
https://www.ncbi.nlm.nih.gov/pubmed/34328417
http://dx.doi.org/10.7554/eLife.60747

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