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Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are locate...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384421/ https://www.ncbi.nlm.nih.gov/pubmed/34425939 http://dx.doi.org/10.7554/eLife.69161 |
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author | Deryckere, Astrid Styfhals, Ruth Elagoz, Ali Murat Maes, Gregory E Seuntjens, Eve |
author_facet | Deryckere, Astrid Styfhals, Ruth Elagoz, Ali Murat Maes, Gregory E Seuntjens, Eve |
author_sort | Deryckere, Astrid |
collection | PubMed |
description | Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development. |
format | Online Article Text |
id | pubmed-8384421 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-83844212021-08-25 Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain Deryckere, Astrid Styfhals, Ruth Elagoz, Ali Murat Maes, Gregory E Seuntjens, Eve eLife Developmental Biology Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development. eLife Sciences Publications, Ltd 2021-08-24 /pmc/articles/PMC8384421/ /pubmed/34425939 http://dx.doi.org/10.7554/eLife.69161 Text en © 2021, Deryckere et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Developmental Biology Deryckere, Astrid Styfhals, Ruth Elagoz, Ali Murat Maes, Gregory E Seuntjens, Eve Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title_full | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title_fullStr | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title_full_unstemmed | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title_short | Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
title_sort | identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain |
topic | Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384421/ https://www.ncbi.nlm.nih.gov/pubmed/34425939 http://dx.doi.org/10.7554/eLife.69161 |
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