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Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain

Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are locate...

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Autores principales: Deryckere, Astrid, Styfhals, Ruth, Elagoz, Ali Murat, Maes, Gregory E, Seuntjens, Eve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384421/
https://www.ncbi.nlm.nih.gov/pubmed/34425939
http://dx.doi.org/10.7554/eLife.69161
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author Deryckere, Astrid
Styfhals, Ruth
Elagoz, Ali Murat
Maes, Gregory E
Seuntjens, Eve
author_facet Deryckere, Astrid
Styfhals, Ruth
Elagoz, Ali Murat
Maes, Gregory E
Seuntjens, Eve
author_sort Deryckere, Astrid
collection PubMed
description Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development.
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spelling pubmed-83844212021-08-25 Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain Deryckere, Astrid Styfhals, Ruth Elagoz, Ali Murat Maes, Gregory E Seuntjens, Eve eLife Developmental Biology Cephalopods have evolved nervous systems that parallel the complexity of mammalian brains in terms of neuronal numbers and richness in behavioral output. How the cephalopod brain develops has only been described at the morphological level, and it remains unclear where the progenitor cells are located and what molecular factors drive neurogenesis. Using histological techniques, we located dividing cells, neural progenitors and postmitotic neurons in Octopus vulgaris embryos. Our results indicate that an important pool of progenitors, expressing the conserved bHLH transcription factors achaete-scute or neurogenin, is located outside the central brain cords in the lateral lips adjacent to the eyes, suggesting that newly formed neurons migrate into the cords. Lineage-tracing experiments then showed that progenitors, depending on their location in the lateral lips, generate neurons for the different lobes, similar to the squid Doryteuthis pealeii. The finding that octopus newborn neurons migrate over long distances is reminiscent of vertebrate neurogenesis and suggests it might be a fundamental strategy for large brain development. eLife Sciences Publications, Ltd 2021-08-24 /pmc/articles/PMC8384421/ /pubmed/34425939 http://dx.doi.org/10.7554/eLife.69161 Text en © 2021, Deryckere et al https://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Developmental Biology
Deryckere, Astrid
Styfhals, Ruth
Elagoz, Ali Murat
Maes, Gregory E
Seuntjens, Eve
Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title_full Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title_fullStr Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title_full_unstemmed Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title_short Identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
title_sort identification of neural progenitor cells and their progeny reveals long distance migration in the developing octopus brain
topic Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384421/
https://www.ncbi.nlm.nih.gov/pubmed/34425939
http://dx.doi.org/10.7554/eLife.69161
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