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The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease
The increasing numbers of elderly Alzheimer's disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384510/ https://www.ncbi.nlm.nih.gov/pubmed/34447487 http://dx.doi.org/10.1155/2021/5568011 |
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author | Zhou, Xiangyu Zhang, Lin |
author_facet | Zhou, Xiangyu Zhang, Lin |
author_sort | Zhou, Xiangyu |
collection | PubMed |
description | The increasing numbers of elderly Alzheimer's disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (200-500 mg/d) and regular caffeine consumption from coffee and tea are considered to alleviate the risk of AD and have therapeutic potential. This paper reviewed epidemiological studies about the relationship of caffeine intake from coffee or/and tea with the risk of AD and summarized the caffeine-related AD therapies based on experimental models. And further well-designed and well-conducted studies are suggested to investigate the optimal dosages, frequencies, and durations of caffeine consumption to slow down AD progression and treat AD. |
format | Online Article Text |
id | pubmed-8384510 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83845102021-08-25 The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease Zhou, Xiangyu Zhang, Lin Oxid Med Cell Longev Review Article The increasing numbers of elderly Alzheimer's disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (200-500 mg/d) and regular caffeine consumption from coffee and tea are considered to alleviate the risk of AD and have therapeutic potential. This paper reviewed epidemiological studies about the relationship of caffeine intake from coffee or/and tea with the risk of AD and summarized the caffeine-related AD therapies based on experimental models. And further well-designed and well-conducted studies are suggested to investigate the optimal dosages, frequencies, and durations of caffeine consumption to slow down AD progression and treat AD. Hindawi 2021-08-17 /pmc/articles/PMC8384510/ /pubmed/34447487 http://dx.doi.org/10.1155/2021/5568011 Text en Copyright © 2021 Xiangyu Zhou and Lin Zhang. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhou, Xiangyu Zhang, Lin The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title | The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title_full | The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title_fullStr | The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title_full_unstemmed | The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title_short | The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease |
title_sort | neuroprotective effects of moderate and regular caffeine consumption in alzheimer's disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384510/ https://www.ncbi.nlm.nih.gov/pubmed/34447487 http://dx.doi.org/10.1155/2021/5568011 |
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