Cargando…
Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications
Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism....
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384524/ https://www.ncbi.nlm.nih.gov/pubmed/34447287 http://dx.doi.org/10.1155/2021/5110276 |
_version_ | 1783741931299274752 |
---|---|
author | Zhang, Lili Chu, Jinjin Hao, Wenhao Zhang, Jiaojiao Li, Haibo Yang, Chunjuan Yang, Jinghan Chen, Xiaohua Wang, Honggang |
author_facet | Zhang, Lili Chu, Jinjin Hao, Wenhao Zhang, Jiaojiao Li, Haibo Yang, Chunjuan Yang, Jinghan Chen, Xiaohua Wang, Honggang |
author_sort | Zhang, Lili |
collection | PubMed |
description | Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism. |
format | Online Article Text |
id | pubmed-8384524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-83845242021-08-25 Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications Zhang, Lili Chu, Jinjin Hao, Wenhao Zhang, Jiaojiao Li, Haibo Yang, Chunjuan Yang, Jinghan Chen, Xiaohua Wang, Honggang Mediators Inflamm Review Article Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism. Short-chain fatty acids, secondary bile acid, imidazole propionate, branched-chain amino acids, and lipopolysaccharide are the main molecules related to T2DM. Many studies have investigated the role of gut microbiota in T2DM, particularly those butyrate-producing bacteria. Increasing evidence has demonstrated that fecal microbiota transplantation and probiotic capsules are useful strategies in preventing diabetes. In this review, we aim to elucidate the complex association between gut microbiota and T2DM inflammation, metabolism, and immune disorders, the underlying mechanisms, and translational applications of gut microbiota. This review will provide novel insight into developing individualized therapy for T2DM patients based on gut microbiota immunometabolism. Hindawi 2021-08-17 /pmc/articles/PMC8384524/ /pubmed/34447287 http://dx.doi.org/10.1155/2021/5110276 Text en Copyright © 2021 Lili Zhang et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Zhang, Lili Chu, Jinjin Hao, Wenhao Zhang, Jiaojiao Li, Haibo Yang, Chunjuan Yang, Jinghan Chen, Xiaohua Wang, Honggang Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title_full | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title_fullStr | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title_full_unstemmed | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title_short | Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications |
title_sort | gut microbiota and type 2 diabetes mellitus: association, mechanism, and translational applications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384524/ https://www.ncbi.nlm.nih.gov/pubmed/34447287 http://dx.doi.org/10.1155/2021/5110276 |
work_keys_str_mv | AT zhanglili gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT chujinjin gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT haowenhao gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT zhangjiaojiao gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT lihaibo gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT yangchunjuan gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT yangjinghan gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT chenxiaohua gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications AT wanghonggang gutmicrobiotaandtype2diabetesmellitusassociationmechanismandtranslationalapplications |