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Illuminating the Fc dependence of SARS-CoV-2 neutralization
Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384580/ https://www.ncbi.nlm.nih.gov/pubmed/34464594 http://dx.doi.org/10.1016/j.immuni.2021.08.024 |
| _version_ | 1783741941340438528 |
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| author | González, Joseph C. Wang, Taia T. |
| author_facet | González, Joseph C. Wang, Taia T. |
| author_sort | González, Joseph C. |
| collection | PubMed |
| description | Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells. |
| format | Online Article Text |
| id | pubmed-8384580 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | Elsevier Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-83845802021-08-25 Illuminating the Fc dependence of SARS-CoV-2 neutralization González, Joseph C. Wang, Taia T. Immunity Preview Monoclonal antibodies show efficacy in treating COVID-19, but the functional requirements for protection are unclear. In this issue of Immunity, Ullah et al. (2021) develop a stable SARS-CoV-2 reporter virus and use bioluminescence imaging to longitudinally monitor infection and assess neutralizing monoclonal antibody interventions in mice. They find that antibody-mediated protection depends on the Fc domain and Fc-gamma receptor-expressing immune cells. Elsevier Inc. 2021-09-14 2021-08-25 /pmc/articles/PMC8384580/ /pubmed/34464594 http://dx.doi.org/10.1016/j.immuni.2021.08.024 Text en © 2021 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Preview González, Joseph C. Wang, Taia T. Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title | Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title_full | Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title_fullStr | Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title_full_unstemmed | Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title_short | Illuminating the Fc dependence of SARS-CoV-2 neutralization |
| title_sort | illuminating the fc dependence of sars-cov-2 neutralization |
| topic | Preview |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384580/ https://www.ncbi.nlm.nih.gov/pubmed/34464594 http://dx.doi.org/10.1016/j.immuni.2021.08.024 |
| work_keys_str_mv | AT gonzalezjosephc illuminatingthefcdependenceofsarscov2neutralization AT wangtaiat illuminatingthefcdependenceofsarscov2neutralization |