PD-L1 degradation is regulated by electrostatic membrane association of its cytoplasmic domain

The cytoplasmic domain of PD-L1 (PD-L1-CD) regulates PD-L1 degradation and stability through various mechanism, making it an attractive target for blocking PD-L1-related cancer signaling. Here, by using NMR and biochemical techniques we find that the membrane association of PD-L1-CD is mediated by e...

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Detalles Bibliográficos
Autores principales: Wen, Maorong, Cao, Yunlei, Wu, Bin, Xiao, Taoran, Cao, Ruiyu, Wang, Qian, Liu, Xiwei, Xue, Hongjuan, Yu, Yang, Lin, Jialing, Xu, Chenqi, Xu, Jie, OuYang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384847/
https://www.ncbi.nlm.nih.gov/pubmed/34429434
http://dx.doi.org/10.1038/s41467-021-25416-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384847/
https://www.ncbi.nlm.nih.gov/pubmed/34429434
http://dx.doi.org/10.1038/s41467-021-25416-7

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