Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire

The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine...

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Autores principales: Patel, Ketan D., Gulick, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Editors' Pick Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384895/
https://www.ncbi.nlm.nih.gov/pubmed/34358564
http://dx.doi.org/10.1016/j.jbc.2021.101047
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author Patel, Ketan D.
Gulick, Andrew M.
author_facet Patel, Ketan D.
Gulick, Andrew M.
author_sort Patel, Ketan D.
collection PubMed
description The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication.
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spelling pubmed-83848952021-08-30 Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire Patel, Ketan D. Gulick, Andrew M. J Biol Chem Editors' Pick Highlight The study of natural products provides exciting opportunities for the discovery of novel biologically active molecules and biosynthetic pathways. Recently, Yuan and colleagues described 30 cyclic depsipeptides that are biosynthesized by proteins encoded by three distinct gene clusters in the marine fungus, Beauveria felina. Genetic and biochemical studies confirmed the involvement of nonribosomal peptide synthetases in the production of multiple compounds, some of which inhibit Zika virus replication. American Society for Biochemistry and Molecular Biology 2021-08-04 /pmc/articles/PMC8384895/ /pubmed/34358564 http://dx.doi.org/10.1016/j.jbc.2021.101047 Text en © 2021 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editors' Pick Highlight
Patel, Ketan D.
Gulick, Andrew M.
Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title_full Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title_fullStr Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title_full_unstemmed Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title_short Anti-Zika candidates from a marine fungus with a remarkable biosynthetic repertoire
title_sort anti-zika candidates from a marine fungus with a remarkable biosynthetic repertoire
topic Editors' Pick Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384895/
https://www.ncbi.nlm.nih.gov/pubmed/34358564
http://dx.doi.org/10.1016/j.jbc.2021.101047
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