ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

Lineage-defining transcription factors (LTFs) play key roles in small-cell lung cancer (SCLC) pathophysiology. Delineating the LTF-regulated genes operative in SCLC could provide a road map to identify SCLC dependencies. We integrated chromatin landscape and transcriptome analyses of patient-derived...

Descripción completa

Detalles Bibliográficos
Autores principales: Pozo, Karine, Kollipara, Rahul K., Kelenis, Demetra P., Rodarte, Kathia E., Ullrich, Morgan S., Zhang, Xiaoyang, Minna, John D., Johnson, Jane E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384902/
https://www.ncbi.nlm.nih.gov/pubmed/34466783
http://dx.doi.org/10.1016/j.isci.2021.102953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384902/
https://www.ncbi.nlm.nih.gov/pubmed/34466783
http://dx.doi.org/10.1016/j.isci.2021.102953

Ejemplares similares