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ASCL1, NKX2-1, and PROX1 co-regulate subtype-specific genes in small-cell lung cancer

Lineage-defining transcription factors (LTFs) play key roles in small-cell lung cancer (SCLC) pathophysiology. Delineating the LTF-regulated genes operative in SCLC could provide a road map to identify SCLC dependencies. We integrated chromatin landscape and transcriptome analyses of patient-derived...

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Detalles Bibliográficos
Autores principales:	Pozo, Karine, Kollipara, Rahul K., Kelenis, Demetra P., Rodarte, Kathia E., Ullrich, Morgan S., Zhang, Xiaoyang, Minna, John D., Johnson, Jane E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8384902/ https://www.ncbi.nlm.nih.gov/pubmed/34466783 http://dx.doi.org/10.1016/j.isci.2021.102953

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