Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil

This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC(50) values ranging from 0.28 to 22.34 μg m...

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Detalles Bibliográficos
Autores principales: Alves, Uesley Vieira, Jardim e Silva, Eujeane, dos Santos, Jailciele Gonzaga, Santos, Luisa Oliveira, Lanna, Emilio, de Souza Pinto, Ana Claudia, Luisa da Fonseca, Amanda, de Pilla Varotti, Fernando, Batista, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385112/
https://www.ncbi.nlm.nih.gov/pubmed/34418583
http://dx.doi.org/10.1016/j.ijpddr.2021.08.002
Descripción
Sumario:This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC(50) values ranging from 0.28 to 22.34 μg mL(−1), and weakly cytotoxic against the human cell line WI-26-VA4 with CC(50) values > 89 μg mL(−1), thus displaying selectivity indices (SI) equal or higher than 17. Interestingly, some SI values exceeded 1,000. The highly potent and selective antiplasmodial activity of the assessed marine sponges is reported for the first time in this study.

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