Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil

This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC(50) values ranging from 0.28 to 22.34 μg m...

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Autores principales: Alves, Uesley Vieira, Jardim e Silva, Eujeane, dos Santos, Jailciele Gonzaga, Santos, Luisa Oliveira, Lanna, Emilio, de Souza Pinto, Ana Claudia, Luisa da Fonseca, Amanda, de Pilla Varotti, Fernando, Batista, Ronan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Regular article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385112/
https://www.ncbi.nlm.nih.gov/pubmed/34418583
http://dx.doi.org/10.1016/j.ijpddr.2021.08.002
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author Alves, Uesley Vieira
Jardim e Silva, Eujeane
dos Santos, Jailciele Gonzaga
Santos, Luisa Oliveira
Lanna, Emilio
de Souza Pinto, Ana Claudia
Luisa da Fonseca, Amanda
de Pilla Varotti, Fernando
Batista, Ronan
author_facet Alves, Uesley Vieira
Jardim e Silva, Eujeane
dos Santos, Jailciele Gonzaga
Santos, Luisa Oliveira
Lanna, Emilio
de Souza Pinto, Ana Claudia
Luisa da Fonseca, Amanda
de Pilla Varotti, Fernando
Batista, Ronan
author_sort Alves, Uesley Vieira
collection PubMed
description This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC(50) values ranging from 0.28 to 22.34 μg mL(−1), and weakly cytotoxic against the human cell line WI-26-VA4 with CC(50) values > 89 μg mL(−1), thus displaying selectivity indices (SI) equal or higher than 17. Interestingly, some SI values exceeded 1,000. The highly potent and selective antiplasmodial activity of the assessed marine sponges is reported for the first time in this study.
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spelling pubmed-83851122021-08-30 Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil Alves, Uesley Vieira Jardim e Silva, Eujeane dos Santos, Jailciele Gonzaga Santos, Luisa Oliveira Lanna, Emilio de Souza Pinto, Ana Claudia Luisa da Fonseca, Amanda de Pilla Varotti, Fernando Batista, Ronan Int J Parasitol Drugs Drug Resist Regular article This study evaluated the in vitro antiplasmodial and cytotoxic effects of 26 extracts from nine marine sponges collected in Salvador, Bahia state, Brazil. All assayed extracts were found to be potently active against Plasmodium falciparum W2 strain, with IC(50) values ranging from 0.28 to 22.34 μg mL(−1), and weakly cytotoxic against the human cell line WI-26-VA4 with CC(50) values > 89 μg mL(−1), thus displaying selectivity indices (SI) equal or higher than 17. Interestingly, some SI values exceeded 1,000. The highly potent and selective antiplasmodial activity of the assessed marine sponges is reported for the first time in this study. Elsevier 2021-08-11 /pmc/articles/PMC8385112/ /pubmed/34418583 http://dx.doi.org/10.1016/j.ijpddr.2021.08.002 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular article
Alves, Uesley Vieira
Jardim e Silva, Eujeane
dos Santos, Jailciele Gonzaga
Santos, Luisa Oliveira
Lanna, Emilio
de Souza Pinto, Ana Claudia
Luisa da Fonseca, Amanda
de Pilla Varotti, Fernando
Batista, Ronan
Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title_full Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title_fullStr Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title_full_unstemmed Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title_short Potent and selective antiplasmodial activity of marine sponges from Bahia state, Brazil
title_sort potent and selective antiplasmodial activity of marine sponges from bahia state, brazil
topic Regular article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385112/
https://www.ncbi.nlm.nih.gov/pubmed/34418583
http://dx.doi.org/10.1016/j.ijpddr.2021.08.002
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