Cargando…
Plasma colloid osmotic pressure in healthy infants
BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for h...
Autores principales: | , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2001
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83852/ https://www.ncbi.nlm.nih.gov/pubmed/11737900 |
_version_ | 1782120185173377024 |
---|---|
author | Sussmane, Jeffrey B de Soto, Maria Torbati, Dan |
author_facet | Sussmane, Jeffrey B de Soto, Maria Torbati, Dan |
author_sort | Sussmane, Jeffrey B |
collection | PubMed |
description | BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults. METHODS: Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses. RESULTS: Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r(2) = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r(2) = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1–3 months [n = 11], 5–8 months [n = 13] and 9–11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg. CONCLUSIONS: The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth. |
format | Text |
id | pubmed-83852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2001 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-838522002-03-15 Plasma colloid osmotic pressure in healthy infants Sussmane, Jeffrey B de Soto, Maria Torbati, Dan Crit Care Research BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults. METHODS: Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses. RESULTS: Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r(2) = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r(2) = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1–3 months [n = 11], 5–8 months [n = 13] and 9–11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg. CONCLUSIONS: The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth. BioMed Central 2001 2001-08-09 /pmc/articles/PMC83852/ /pubmed/11737900 Text en Copyright © 2001 BioMed Central Ltd |
spellingShingle | Research Sussmane, Jeffrey B de Soto, Maria Torbati, Dan Plasma colloid osmotic pressure in healthy infants |
title | Plasma colloid osmotic pressure in healthy infants |
title_full | Plasma colloid osmotic pressure in healthy infants |
title_fullStr | Plasma colloid osmotic pressure in healthy infants |
title_full_unstemmed | Plasma colloid osmotic pressure in healthy infants |
title_short | Plasma colloid osmotic pressure in healthy infants |
title_sort | plasma colloid osmotic pressure in healthy infants |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83852/ https://www.ncbi.nlm.nih.gov/pubmed/11737900 |
work_keys_str_mv | AT sussmanejeffreyb plasmacolloidosmoticpressureinhealthyinfants AT desotomaria plasmacolloidosmoticpressureinhealthyinfants AT torbatidan plasmacolloidosmoticpressureinhealthyinfants |