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Plasma colloid osmotic pressure in healthy infants

BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for h...

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Autores principales: Sussmane, Jeffrey B, de Soto, Maria, Torbati, Dan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2001
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83852/
https://www.ncbi.nlm.nih.gov/pubmed/11737900
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author Sussmane, Jeffrey B
de Soto, Maria
Torbati, Dan
author_facet Sussmane, Jeffrey B
de Soto, Maria
Torbati, Dan
author_sort Sussmane, Jeffrey B
collection PubMed
description BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults. METHODS: Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses. RESULTS: Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r(2) = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r(2) = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1–3 months [n = 11], 5–8 months [n = 13] and 9–11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg. CONCLUSIONS: The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth.
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spelling pubmed-838522002-03-15 Plasma colloid osmotic pressure in healthy infants Sussmane, Jeffrey B de Soto, Maria Torbati, Dan Crit Care Research BACKGROUND: The plasma colloid osmotic pressure (COP) plays a major role in transcapillary fluid balance. There is no information on plasma COP of healthy infants beyond the first post-natal week. The normal COP in healthy adult subjects (25 mmHg) is currently also applied as a reference value for healthy infants. This study was designed to test whether plasma COP values in healthy infants are the same as those in normal adults. METHODS: Plasma COP was measured in 37 male and female healthy infants from 1 to 11 months old. For this purpose, 1 ml blood was collected during the patient's regularly scheduled visit if the patient required any type of blood test for routine laboratory analyses. RESULTS: Plasma COP levels correlated slightly with increasing age from 1 to 9 months old (linear regression analysis; r(2) = 0.1, P < 0.049). We found no correlation between plasma COP and body weight at the same age (r(2) = 0.05, P = 0.155). The mean and standard deviation of COP in all infants was 25.1 ± 2.6 mmHg, which is almost identical to an average COP of 25 mmHg in healthy adult subjects. Arbitrary division of the infants into three different age groups (1–3 months [n = 11], 5–8 months [n = 13] and 9–11 months [n = 13]) showed an average increase of approximately 2 mmHg in COP of 9-month-old to 11-month-old infants, compared with 1-month-old to 3-month-old infants (one-way analysis of variance; P = 0.26). There was no gender difference in the COP level (unpaired t-test), with an average of 25.1 ± 2.4 mmHg in 19 male infants compared with 25.2 ± 2.9 in 18 female infants. The 95% confidence interval for COP in both male and female infants (n = 37) was between 24.3 to 26.0 mmHg, ranging from 19.5 to 30.3 mmHg, with a median value of 25.2 mmHg. CONCLUSIONS: The data accept the null hypothesis that the COP range in infants younger than 1 year old is similar to those observed in adult subjects. Our observations, compared with previously reported neonatal COP values, suggest that there is a sharp increase in COP within the first months after birth. BioMed Central 2001 2001-08-09 /pmc/articles/PMC83852/ /pubmed/11737900 Text en Copyright © 2001 BioMed Central Ltd
spellingShingle Research
Sussmane, Jeffrey B
de Soto, Maria
Torbati, Dan
Plasma colloid osmotic pressure in healthy infants
title Plasma colloid osmotic pressure in healthy infants
title_full Plasma colloid osmotic pressure in healthy infants
title_fullStr Plasma colloid osmotic pressure in healthy infants
title_full_unstemmed Plasma colloid osmotic pressure in healthy infants
title_short Plasma colloid osmotic pressure in healthy infants
title_sort plasma colloid osmotic pressure in healthy infants
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC83852/
https://www.ncbi.nlm.nih.gov/pubmed/11737900
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