An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia

• We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation. • Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD. • The structure of tau filaments associated with MAPT...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Ryohei, Kawakami, Ito, Ikeuchi, Takeshi, Murayama, Shigeo, Arai, Tetsuaki, Akiyama, Haruhiko, Onaya, Mitsumoto, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385289/
https://www.ncbi.nlm.nih.gov/pubmed/34466673
http://dx.doi.org/10.1016/j.ensci.2021.100363
Descripción
Sumario:• We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation. • Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD. • The structure of tau filaments associated with MAPT IVS 10 + 14C > T mutation was characterized by electron microscopy.

Ejemplares similares