An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia

• We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation. • Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD. • The structure of tau filaments associated with MAPT...

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Autores principales: Watanabe, Ryohei, Kawakami, Ito, Ikeuchi, Takeshi, Murayama, Shigeo, Arai, Tetsuaki, Akiyama, Haruhiko, Onaya, Mitsumoto, Hasegawa, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385289/
https://www.ncbi.nlm.nih.gov/pubmed/34466673
http://dx.doi.org/10.1016/j.ensci.2021.100363
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author Watanabe, Ryohei
Kawakami, Ito
Ikeuchi, Takeshi
Murayama, Shigeo
Arai, Tetsuaki
Akiyama, Haruhiko
Onaya, Mitsumoto
Hasegawa, Masato
author_facet Watanabe, Ryohei
Kawakami, Ito
Ikeuchi, Takeshi
Murayama, Shigeo
Arai, Tetsuaki
Akiyama, Haruhiko
Onaya, Mitsumoto
Hasegawa, Masato
author_sort Watanabe, Ryohei
collection PubMed
description • We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation. • Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD. • The structure of tau filaments associated with MAPT IVS 10 + 14C > T mutation was characterized by electron microscopy.
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spelling pubmed-83852892021-08-30 An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia Watanabe, Ryohei Kawakami, Ito Ikeuchi, Takeshi Murayama, Shigeo Arai, Tetsuaki Akiyama, Haruhiko Onaya, Mitsumoto Hasegawa, Masato eNeurologicalSci Letter to the Editor • We report the immunohistochemical and biochemical features of an FTDP-17 case with MAPT IVS 10 + 14C > T mutation. • Postmortem examination of the patient with bvFTD revealed diffuse neuronal and glial 4-repeat tau pathology similar to CBD. • The structure of tau filaments associated with MAPT IVS 10 + 14C > T mutation was characterized by electron microscopy. Elsevier 2021-07-28 /pmc/articles/PMC8385289/ /pubmed/34466673 http://dx.doi.org/10.1016/j.ensci.2021.100363 Text en © 2021 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Letter to the Editor
Watanabe, Ryohei
Kawakami, Ito
Ikeuchi, Takeshi
Murayama, Shigeo
Arai, Tetsuaki
Akiyama, Haruhiko
Onaya, Mitsumoto
Hasegawa, Masato
An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title_full An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title_fullStr An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title_full_unstemmed An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title_short An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia
title_sort autopsied ftdp-17 case with mapt ivs 10 + 14c > t mutation presenting with frontotemporal dementia
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385289/
https://www.ncbi.nlm.nih.gov/pubmed/34466673
http://dx.doi.org/10.1016/j.ensci.2021.100363
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