Mutant HER2 needs mutant HER3 to be an effective oncogene

Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.

Detalles Bibliográficos
Autores principales: Trenker, Raphael, Diwanji, Devan, Jura, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Preview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385292/
https://www.ncbi.nlm.nih.gov/pubmed/34467245
http://dx.doi.org/10.1016/j.xcrm.2021.100361
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author Trenker, Raphael
Diwanji, Devan
Jura, Natalia
author_facet Trenker, Raphael
Diwanji, Devan
Jura, Natalia
author_sort Trenker, Raphael
collection PubMed
description Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.
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spelling pubmed-83852922021-08-30 Mutant HER2 needs mutant HER3 to be an effective oncogene Trenker, Raphael Diwanji, Devan Jura, Natalia Cell Rep Med Preview Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex. Elsevier 2021-08-06 /pmc/articles/PMC8385292/ /pubmed/34467245 http://dx.doi.org/10.1016/j.xcrm.2021.100361 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preview
Trenker, Raphael
Diwanji, Devan
Jura, Natalia
Mutant HER2 needs mutant HER3 to be an effective oncogene
title Mutant HER2 needs mutant HER3 to be an effective oncogene
title_full Mutant HER2 needs mutant HER3 to be an effective oncogene
title_fullStr Mutant HER2 needs mutant HER3 to be an effective oncogene
title_full_unstemmed Mutant HER2 needs mutant HER3 to be an effective oncogene
title_short Mutant HER2 needs mutant HER3 to be an effective oncogene
title_sort mutant her2 needs mutant her3 to be an effective oncogene
topic Preview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385292/
https://www.ncbi.nlm.nih.gov/pubmed/34467245
http://dx.doi.org/10.1016/j.xcrm.2021.100361
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AT juranatalia mutanther2needsmutanther3tobeaneffectiveoncogene

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