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Mutant HER2 needs mutant HER3 to be an effective oncogene
Hanker et al. reveal that co-occurring missense mutations in the human epidermal growth factor receptor 2 (HER2) and its catalytically inactive homolog HER3 synergize to promote oncogenic signaling by the HER2/HER3 complex.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385292/ https://www.ncbi.nlm.nih.gov/pubmed/34467245 http://dx.doi.org/10.1016/j.xcrm.2021.100361 |