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Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy

Adoptive transfer of T cells expressing a transgenic T cell receptor (TCR) has the potential to revolutionize immunotherapy of infectious diseases and cancer. However, the generation of defined TCR-transgenic T cell medicinal products with predictable in vivo function still poses a major challenge a...

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Detalles Bibliográficos
Autores principales: Müller, Thomas R., Jarosch, Sebastian, Hammel, Monika, Leube, Justin, Grassmann, Simon, Bernard, Bettina, Effenberger, Manuel, Andrä, Immanuel, Chaudhry, M. Zeeshan, Käuferle, Theresa, Malo, Antje, Cicin-Sain, Luka, Steinberger, Peter, Feuchtinger, Tobias, Protzer, Ulrike, Schumann, Kathrin, Neuenhahn, Michael, Schober, Kilian, Busch, Dirk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385324/
https://www.ncbi.nlm.nih.gov/pubmed/34467251
http://dx.doi.org/10.1016/j.xcrm.2021.100374