Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report

This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.

Detalles Bibliográficos
Autores principales: Takeuchi, Yu, Noritake, Hidenao, Matsumoto, Moe, Umemura, Masahiro, Yamashita, Maho, Kitsugi, Kensuke, Takatori, Shingo, Ohta, Kazuyoshi, Ito, Jun, Shimoyama, Shin, Kaysuya, Akira, Maruyama, Chiaki, Fukuchi, Kensuke, Dohtan, Satoshi, Sakata, Hiroe, Kawata, Kazuhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385330/
https://www.ncbi.nlm.nih.gov/pubmed/34466252
http://dx.doi.org/10.1002/ccr3.4696
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author Takeuchi, Yu
Noritake, Hidenao
Matsumoto, Moe
Umemura, Masahiro
Yamashita, Maho
Kitsugi, Kensuke
Takatori, Shingo
Ohta, Kazuyoshi
Ito, Jun
Shimoyama, Shin
Kaysuya, Akira
Maruyama, Chiaki
Fukuchi, Kensuke
Dohtan, Satoshi
Sakata, Hiroe
Kawata, Kazuhito
author_facet Takeuchi, Yu
Noritake, Hidenao
Matsumoto, Moe
Umemura, Masahiro
Yamashita, Maho
Kitsugi, Kensuke
Takatori, Shingo
Ohta, Kazuyoshi
Ito, Jun
Shimoyama, Shin
Kaysuya, Akira
Maruyama, Chiaki
Fukuchi, Kensuke
Dohtan, Satoshi
Sakata, Hiroe
Kawata, Kazuhito
author_sort Takeuchi, Yu
collection PubMed
description This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction.
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spelling pubmed-83853302021-08-30 Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report Takeuchi, Yu Noritake, Hidenao Matsumoto, Moe Umemura, Masahiro Yamashita, Maho Kitsugi, Kensuke Takatori, Shingo Ohta, Kazuyoshi Ito, Jun Shimoyama, Shin Kaysuya, Akira Maruyama, Chiaki Fukuchi, Kensuke Dohtan, Satoshi Sakata, Hiroe Kawata, Kazuhito Clin Case Rep Case Report This report highlights azathioprine‐induced severe myelosuppression in the patient with NUDT15 minor variant. This case report is particularly instructive because several typical symptoms are the clues to this critical adverse drug reaction. John Wiley and Sons Inc. 2021-08-25 /pmc/articles/PMC8385330/ /pubmed/34466252 http://dx.doi.org/10.1002/ccr3.4696 Text en © 2021 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Case Report
Takeuchi, Yu
Noritake, Hidenao
Matsumoto, Moe
Umemura, Masahiro
Yamashita, Maho
Kitsugi, Kensuke
Takatori, Shingo
Ohta, Kazuyoshi
Ito, Jun
Shimoyama, Shin
Kaysuya, Akira
Maruyama, Chiaki
Fukuchi, Kensuke
Dohtan, Satoshi
Sakata, Hiroe
Kawata, Kazuhito
Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title_full Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title_fullStr Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title_full_unstemmed Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title_short Azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with NUDT15 minor variant: A case report
title_sort azathioprine‐induced severe myelosuppression accompanied by massive hair loss and painful oral ulcer in an autoimmune hepatitis patient with nudt15 minor variant: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385330/
https://www.ncbi.nlm.nih.gov/pubmed/34466252
http://dx.doi.org/10.1002/ccr3.4696
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