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Primary cilia and lipid raft dynamics

Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs...

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Detalles Bibliográficos
Autores principales: Nishimura, Yuhei, Yamakawa, Daishi, Uchida, Katsunori, Shiromizu, Takashi, Watanabe, Masatoshi, Inagaki, Masaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385361/
https://www.ncbi.nlm.nih.gov/pubmed/34428960
http://dx.doi.org/10.1098/rsob.210130
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author Nishimura, Yuhei
Yamakawa, Daishi
Uchida, Katsunori
Shiromizu, Takashi
Watanabe, Masatoshi
Inagaki, Masaki
author_facet Nishimura, Yuhei
Yamakawa, Daishi
Uchida, Katsunori
Shiromizu, Takashi
Watanabe, Masatoshi
Inagaki, Masaki
author_sort Nishimura, Yuhei
collection PubMed
description Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions. Although impairment of primary cilia and lipid rafts is associated with various diseases, the relationship between primary cilia and lipid rafts is poorly understood. Here, we review a newly discovered interaction between primary cilia and lipid raft dynamics that occurs during Akt signalling in adipogenesis. We also discuss the relationship between primary cilia and lipid raft-mediated Akt signalling in cancer biology. This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics.
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spelling pubmed-83853612021-12-14 Primary cilia and lipid raft dynamics Nishimura, Yuhei Yamakawa, Daishi Uchida, Katsunori Shiromizu, Takashi Watanabe, Masatoshi Inagaki, Masaki Open Biol Review Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions. Although impairment of primary cilia and lipid rafts is associated with various diseases, the relationship between primary cilia and lipid rafts is poorly understood. Here, we review a newly discovered interaction between primary cilia and lipid raft dynamics that occurs during Akt signalling in adipogenesis. We also discuss the relationship between primary cilia and lipid raft-mediated Akt signalling in cancer biology. This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics. The Royal Society 2021-08-25 /pmc/articles/PMC8385361/ /pubmed/34428960 http://dx.doi.org/10.1098/rsob.210130 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited.
spellingShingle Review
Nishimura, Yuhei
Yamakawa, Daishi
Uchida, Katsunori
Shiromizu, Takashi
Watanabe, Masatoshi
Inagaki, Masaki
Primary cilia and lipid raft dynamics
title Primary cilia and lipid raft dynamics
title_full Primary cilia and lipid raft dynamics
title_fullStr Primary cilia and lipid raft dynamics
title_full_unstemmed Primary cilia and lipid raft dynamics
title_short Primary cilia and lipid raft dynamics
title_sort primary cilia and lipid raft dynamics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385361/
https://www.ncbi.nlm.nih.gov/pubmed/34428960
http://dx.doi.org/10.1098/rsob.210130
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