Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation

The three common alleles of the APOE gene, ɛ2/ɛ3/ɛ4, have been linked to human spatial orientation. We investigated the genetic role of APOE in developmental topographical disorientation (DTD), a lifelong condition that results in topographical disorientation. We genotyped the APOE ɛ2/ɛ3/ɛ4 alleles...

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Autores principales: Barclay, Sarah F., Potocki, Kendra, Burles, Ford, Bech-Hansen, N. Torben, Iaria, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2021
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385428/
https://www.ncbi.nlm.nih.gov/pubmed/34514340
http://dx.doi.org/10.3233/ADR-210304
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author Barclay, Sarah F.
Potocki, Kendra
Burles, Ford
Bech-Hansen, N. Torben
Iaria, Giuseppe
author_facet Barclay, Sarah F.
Potocki, Kendra
Burles, Ford
Bech-Hansen, N. Torben
Iaria, Giuseppe
author_sort Barclay, Sarah F.
collection PubMed
description The three common alleles of the APOE gene, ɛ2/ɛ3/ɛ4, have been linked to human spatial orientation. We investigated the genetic role of APOE in developmental topographical disorientation (DTD), a lifelong condition that results in topographical disorientation. We genotyped the APOE ɛ2/ɛ3/ɛ4 alleles in a cohort of 20 unrelated DTD probands, and found allele frequencies not statistically different from the those seen in the population as a whole. Therefore, we found no evidence that DTD occurs preferentially on a genetic background containing any particular APOE allele, making it unlikely that these APOE alleles are contributing to the development of DTD.
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spelling pubmed-83854282021-09-09 Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation Barclay, Sarah F. Potocki, Kendra Burles, Ford Bech-Hansen, N. Torben Iaria, Giuseppe J Alzheimers Dis Rep Short Communication The three common alleles of the APOE gene, ɛ2/ɛ3/ɛ4, have been linked to human spatial orientation. We investigated the genetic role of APOE in developmental topographical disorientation (DTD), a lifelong condition that results in topographical disorientation. We genotyped the APOE ɛ2/ɛ3/ɛ4 alleles in a cohort of 20 unrelated DTD probands, and found allele frequencies not statistically different from the those seen in the population as a whole. Therefore, we found no evidence that DTD occurs preferentially on a genetic background containing any particular APOE allele, making it unlikely that these APOE alleles are contributing to the development of DTD. IOS Press 2021-07-19 /pmc/articles/PMC8385428/ /pubmed/34514340 http://dx.doi.org/10.3233/ADR-210304 Text en © 2021 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Barclay, Sarah F.
Potocki, Kendra
Burles, Ford
Bech-Hansen, N. Torben
Iaria, Giuseppe
Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title_full Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title_fullStr Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title_full_unstemmed Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title_short Evaluation of APOE ɛ2/ɛ3/ɛ4 Alleles in a Cohort of Individuals Affected by Developmental Topographical Disorientation
title_sort evaluation of apoe ɛ2/ɛ3/ɛ4 alleles in a cohort of individuals affected by developmental topographical disorientation
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385428/
https://www.ncbi.nlm.nih.gov/pubmed/34514340
http://dx.doi.org/10.3233/ADR-210304
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