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Mild Microglial Responses in the Cortex and Perivascular Macrophage Infiltration in Subcortical White Matter in Dogs with Age-Related Dementia Modelling Prodromal Alzheimer’s Disease

BACKGROUND: Microglia contribute to Alzheimer’s disease (AD) pathogenesis by clearing amyloid-β (Aβ) and driving neuroinflammation. Domestic dogs with age-related dementia (canine cognitive dysfunction (CCD)) develop cerebral amyloidosis like humans developing AD, and studying such dogs can provide...

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Detalles Bibliográficos
Autores principales:	Thomsen, Barbara Blicher, Madsen, Cecilie, Krohn, Katrine Tækker, Thygesen, Camilla, Schütt, Trine, Metaxas, Athanasios, Darvesh, Sultan, Agerholm, Jørgen Steen, Wirenfeldt, Martin, Berendt, Mette, Finsen, Bente
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385501/ https://www.ncbi.nlm.nih.gov/pubmed/34057083 http://dx.doi.org/10.3233/JAD-210040

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