Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1

Meiotic crossover formation requires the activity of multiple pro-crossover factors, including the MutSγ complex and the cyclin-related protein COSA-1, that become concentrated together at the sites of crossover recombination intermediates. Here we show that a transgene insertion expressing GFP::COS...

Descripción completa

Detalles Bibliográficos
Autores principales: Girard, Chloé, Akerib, Chantal C, Villeneuve, Anne M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2021
Materias:
New Finding
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385548/
https://www.ncbi.nlm.nih.gov/pubmed/34458691
http://dx.doi.org/10.17912/micropub.biology.000430
_version_ 1783742115926245376
author Girard, Chloé
Akerib, Chantal C
Villeneuve, Anne M
author_facet Girard, Chloé
Akerib, Chantal C
Villeneuve, Anne M
author_sort Girard, Chloé
collection PubMed
description Meiotic crossover formation requires the activity of multiple pro-crossover factors, including the MutSγ complex and the cyclin-related protein COSA-1, that become concentrated together at the sites of crossover recombination intermediates. Here we show that a transgene insertion expressing GFP::COSA-1 can suppress the crossover deficit caused by a partial reduction in MutSγ function. Our data, combined with previous findings, support a model in which COSA-1 promotes crossover formation, at least in part, through positive regulation of MutSγ function.
format Online
Article
Text
id pubmed-8385548
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Caltech Library
record_format MEDLINE/PubMed
spelling pubmed-83855482021-08-26 Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1 Girard, Chloé Akerib, Chantal C Villeneuve, Anne M MicroPubl Biol New Finding Meiotic crossover formation requires the activity of multiple pro-crossover factors, including the MutSγ complex and the cyclin-related protein COSA-1, that become concentrated together at the sites of crossover recombination intermediates. Here we show that a transgene insertion expressing GFP::COSA-1 can suppress the crossover deficit caused by a partial reduction in MutSγ function. Our data, combined with previous findings, support a model in which COSA-1 promotes crossover formation, at least in part, through positive regulation of MutSγ function. Caltech Library 2021-08-24 /pmc/articles/PMC8385548/ /pubmed/34458691 http://dx.doi.org/10.17912/micropub.biology.000430 Text en Copyright: © 2021 by the authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle New Finding
Girard, Chloé
Akerib, Chantal C
Villeneuve, Anne M
Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title_full Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title_fullStr Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title_full_unstemmed Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title_short Suppression of him-14(it44ts) by a transgene insertion expressing GFP::COSA-1
title_sort suppression of him-14(it44ts) by a transgene insertion expressing gfp::cosa-1
topic New Finding
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385548/
https://www.ncbi.nlm.nih.gov/pubmed/34458691
http://dx.doi.org/10.17912/micropub.biology.000430
work_keys_str_mv AT girardchloe suppressionofhim14it44tsbyatransgeneinsertionexpressinggfpcosa1
AT akeribchantalc suppressionofhim14it44tsbyatransgeneinsertionexpressinggfpcosa1
AT villeneuveannem suppressionofhim14it44tsbyatransgeneinsertionexpressinggfpcosa1

Ejemplares similares