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Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model

In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain c...

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Autores principales: Gibb, Andrew A., Murray, Emma K., Eaton, Deborah M., Huynh, Anh T., Tomar, Dhanendra, Garbincius, Joanne F., Kolmetzky, Devin W., Berretta, Remus M., Wallner, Markus, Houser, Steven R., Elrod, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385567/
https://www.ncbi.nlm.nih.gov/pubmed/34466752
http://dx.doi.org/10.1016/j.jacbts.2021.07.004
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author Gibb, Andrew A.
Murray, Emma K.
Eaton, Deborah M.
Huynh, Anh T.
Tomar, Dhanendra
Garbincius, Joanne F.
Kolmetzky, Devin W.
Berretta, Remus M.
Wallner, Markus
Houser, Steven R.
Elrod, John W.
author_facet Gibb, Andrew A.
Murray, Emma K.
Eaton, Deborah M.
Huynh, Anh T.
Tomar, Dhanendra
Garbincius, Joanne F.
Kolmetzky, Devin W.
Berretta, Remus M.
Wallner, Markus
Houser, Steven R.
Elrod, John W.
author_sort Gibb, Andrew A.
collection PubMed
description In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression.
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spelling pubmed-83855672021-08-30 Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model Gibb, Andrew A. Murray, Emma K. Eaton, Deborah M. Huynh, Anh T. Tomar, Dhanendra Garbincius, Joanne F. Kolmetzky, Devin W. Berretta, Remus M. Wallner, Markus Houser, Steven R. Elrod, John W. JACC Basic Transl Sci Preclinical Research In this study the authors used systems biology to define progressive changes in metabolism and transcription in a large animal model of heart failure with preserved ejection fraction (HFpEF). Transcriptomic analysis of cardiac tissue, 1-month post-banding, revealed loss of electron transport chain components, and this was supported by changes in metabolism and mitochondrial function, altogether signifying alterations in oxidative metabolism. Established HFpEF, 4 months post-banding, resulted in changes in intermediary metabolism with normalized mitochondrial function. Mitochondrial dysfunction and energetic deficiencies were noted in skeletal muscle at early and late phases of disease, suggesting cardiac-derived signaling contributes to peripheral tissue maladaptation in HFpEF. Collectively, these results provide insights into the cellular biology underlying HFpEF progression. Elsevier 2021-08-23 /pmc/articles/PMC8385567/ /pubmed/34466752 http://dx.doi.org/10.1016/j.jacbts.2021.07.004 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Preclinical Research
Gibb, Andrew A.
Murray, Emma K.
Eaton, Deborah M.
Huynh, Anh T.
Tomar, Dhanendra
Garbincius, Joanne F.
Kolmetzky, Devin W.
Berretta, Remus M.
Wallner, Markus
Houser, Steven R.
Elrod, John W.
Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title_full Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title_fullStr Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title_full_unstemmed Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title_short Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model
title_sort molecular signature of hfpef: systems biology in a cardiac-centric large animal model
topic Preclinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385567/
https://www.ncbi.nlm.nih.gov/pubmed/34466752
http://dx.doi.org/10.1016/j.jacbts.2021.07.004
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