HIV-1 Nef interacts with the cyclin K/CDK13 complex to antagonize SERINC5 for optimal viral infectivity

HIV-1-negative factor (Nef) protein antagonizes serine incorporator 5 (SERINC5) by redirecting this potent restriction factor to the endosomes and lysosomes for degradation. However, the precise mechanism remains unclear. Using affinity purification/mass spectrometry, we identify cyclin K (CycK) and...

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Detalles Bibliográficos
Autores principales: Chai, Qingqing, Li, Sunan, Collins, Morgan K., Li, Rongrong, Ahmad, Iqbal, Johnson, Silas F., Frabutt, Dylan A., Yang, Zhichang, Shen, Xiaojing, Sun, Liangliang, Hu, Jian, Hultquist, Judd F., Peterlin, B. Matija, Zheng, Yong-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385645/
https://www.ncbi.nlm.nih.gov/pubmed/34380030
http://dx.doi.org/10.1016/j.celrep.2021.109514

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385645/
https://www.ncbi.nlm.nih.gov/pubmed/34380030
http://dx.doi.org/10.1016/j.celrep.2021.109514

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