The SARS-CoV-2 spike L452R-E484Q variant in the Indian B.1.617 strain showed significant reduction in the neutralization activity of immune sera

To assess the impact of the key non-synonymous amino acid substitutions in the RBD of the spike protein of SARS-CoV-2 variant B.1.617.1 (dominant variant identified in the current India outbreak) on the infectivity and neutralization activities of the immune sera, L452R and E484Q (L452R-E484Q varian...

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Detalles Bibliográficos
Autores principales: Li, Gen, Zhou, Zhongcheng, Du, Peng, Yu, Meixing, Li, Ning, Xiong, Xinxin, Huang, Hong, Liu, Zhihai, Dai, Qinjin, Zhu, Jie, Guo, Chengbin, Wu, Shanyun, Baptista-Hon, Daniel T, Miao, Man, Ming, Lam Wai, Wu, Yong, Zeng, Fanxin, Zhang, Charlotte L, Zhang, Edward D, Song, Haifeng, Liu, Jianghai, Lau, Johnson Yiu-Nam, Xiang, Andy P, Zhang, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8385834/
https://www.ncbi.nlm.nih.gov/pubmed/35693215
http://dx.doi.org/10.1093/pcmedi/pbab016

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