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Nanobody-armed T cells endow CAR-T cells with cytotoxicity against lymphoma cells

BACKGROUND: Taking advantage of nanobodies (Nbs) in immunotherapy, we investigated the cytotoxicity of Nb-based chimeric antigen receptor T cells (Nb CAR-T) against lymphoma cells. METHODS: CD19 Nb CAR-T, CD20 Nb CAR-T, and Bispecific Nb CAR-T cells were generated by panning anti-human CD19- and CD2...

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Detalles Bibliográficos
Autores principales:	Wang, Hongxia, Wang, Liyan, Li, Yanning, Li, Guangqi, Zhang, Xiaochun, Jiang, Dan, Zhang, Yanting, Liu, Liyuan, Chu, Yuankui, Xu, Guangxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386010/ https://www.ncbi.nlm.nih.gov/pubmed/34429118 http://dx.doi.org/10.1186/s12935-021-02151-z

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