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A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

UDP-N-acetylglucosamine pyrophosphorylase (UAP1) catalyses the last step in eukaryotic biosynthesis of uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc), converting UTP and GlcNAc-1P to the sugar nucleotide. Gene disruption studies have shown that this gene is essential in eukaryotes and a possib...

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Detalles Bibliográficos
Autores principales:	Raimi, Olawale G., Hurtado-Guerrero, Ramon, Borodkin, Vladimir, Ferenbach, Andrew, Urbaniak, Michael D., Ferguson, Michael A. J., van Aalten, Daan M. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	RSC 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386105/ https://www.ncbi.nlm.nih.gov/pubmed/34458745 http://dx.doi.org/10.1039/c9cb00017h

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