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Preclinical Characterization of a Novel Anti-Cancer PD-L1 Inhibitor RPH-120

RPH-120 is a novel fully human anti-PD-L1 IgG1 monoclonal antibody with specifically designed Asn300Ala mutation in Fc fragment. Surface plasmon resonance assay showed that affinity of the RPH-120 to the dimeric form of human PD-L1-Fc fusion protein was much higher than affinity to the monomeric His...

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Detalles Bibliográficos
Autores principales:	Kulikov, Andrey, Shipaeva, Elena, Dmitrieva, Anastasia, Batrak, Vera, Shipunov, Georgy, Guy, Colin, Smith, Jill, Zhang, Ran, Zhang, Michael, Duan, Jeff, Chestukhin, Anton, Barbashov, Sergei, Samsonov, Mikhail, Lavrovsky, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386121/ https://www.ncbi.nlm.nih.gov/pubmed/34456733 http://dx.doi.org/10.3389/fphar.2021.723038

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