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Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma

AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Der...

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Autores principales: Sequeira, Joyce, Sengupta, Shreya, Mhatre, Bhupendra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386270/
https://www.ncbi.nlm.nih.gov/pubmed/34483581
http://dx.doi.org/10.4103/njms.NJMS_242_20
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author Sequeira, Joyce
Sengupta, Shreya
Mhatre, Bhupendra
author_facet Sequeira, Joyce
Sengupta, Shreya
Mhatre, Bhupendra
author_sort Sequeira, Joyce
collection PubMed
description AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Deralakatte, Mangalore. Sample comprises of 25 cases of clinically and histologically diagnosed oral cancer and 25 normal healthy individuals as control group. The serum was analyzed for β2-M by enzyme-linked immunosorbent assay. RESULTS: It was observed that there was a significant increase in serum β2-M levels in oral SCC patients as compared to controls. Circulating levels in serum β2-M were also elevated significantly among different clinical stages with progressive rise from stage I to stage IV of the disease. CONCLUSION: The evaluation of these markers would be useful in assessing malignant change, increasing accuracy of clinical diagnosis and also in assessing the spread and invasiveness of the cancer of the oral cavity.
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spelling pubmed-83862702021-09-03 Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma Sequeira, Joyce Sengupta, Shreya Mhatre, Bhupendra Natl J Maxillofac Surg Original Article AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Deralakatte, Mangalore. Sample comprises of 25 cases of clinically and histologically diagnosed oral cancer and 25 normal healthy individuals as control group. The serum was analyzed for β2-M by enzyme-linked immunosorbent assay. RESULTS: It was observed that there was a significant increase in serum β2-M levels in oral SCC patients as compared to controls. Circulating levels in serum β2-M were also elevated significantly among different clinical stages with progressive rise from stage I to stage IV of the disease. CONCLUSION: The evaluation of these markers would be useful in assessing malignant change, increasing accuracy of clinical diagnosis and also in assessing the spread and invasiveness of the cancer of the oral cavity. Wolters Kluwer - Medknow 2021 2021-07-15 /pmc/articles/PMC8386270/ /pubmed/34483581 http://dx.doi.org/10.4103/njms.NJMS_242_20 Text en Copyright: © 2021 National Journal of Maxillofacial Surgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Sequeira, Joyce
Sengupta, Shreya
Mhatre, Bhupendra
Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title_full Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title_fullStr Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title_full_unstemmed Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title_short Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
title_sort serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386270/
https://www.ncbi.nlm.nih.gov/pubmed/34483581
http://dx.doi.org/10.4103/njms.NJMS_242_20
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