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Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma
AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Der...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386270/ https://www.ncbi.nlm.nih.gov/pubmed/34483581 http://dx.doi.org/10.4103/njms.NJMS_242_20 |
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author | Sequeira, Joyce Sengupta, Shreya Mhatre, Bhupendra |
author_facet | Sequeira, Joyce Sengupta, Shreya Mhatre, Bhupendra |
author_sort | Sequeira, Joyce |
collection | PubMed |
description | AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Deralakatte, Mangalore. Sample comprises of 25 cases of clinically and histologically diagnosed oral cancer and 25 normal healthy individuals as control group. The serum was analyzed for β2-M by enzyme-linked immunosorbent assay. RESULTS: It was observed that there was a significant increase in serum β2-M levels in oral SCC patients as compared to controls. Circulating levels in serum β2-M were also elevated significantly among different clinical stages with progressive rise from stage I to stage IV of the disease. CONCLUSION: The evaluation of these markers would be useful in assessing malignant change, increasing accuracy of clinical diagnosis and also in assessing the spread and invasiveness of the cancer of the oral cavity. |
format | Online Article Text |
id | pubmed-8386270 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-83862702021-09-03 Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma Sequeira, Joyce Sengupta, Shreya Mhatre, Bhupendra Natl J Maxillofac Surg Original Article AIM: This study aims to compare the level of serum beta-2 microglobulin (β2-M) in normal healthy individuals and patient with squamous cell carcinoma (SCC). METHODOLOGY: This study has been conducted in patients attending the Department of Oral and Maxillofacial Surgery, Yenepoya Dental College, Deralakatte, Mangalore. Sample comprises of 25 cases of clinically and histologically diagnosed oral cancer and 25 normal healthy individuals as control group. The serum was analyzed for β2-M by enzyme-linked immunosorbent assay. RESULTS: It was observed that there was a significant increase in serum β2-M levels in oral SCC patients as compared to controls. Circulating levels in serum β2-M were also elevated significantly among different clinical stages with progressive rise from stage I to stage IV of the disease. CONCLUSION: The evaluation of these markers would be useful in assessing malignant change, increasing accuracy of clinical diagnosis and also in assessing the spread and invasiveness of the cancer of the oral cavity. Wolters Kluwer - Medknow 2021 2021-07-15 /pmc/articles/PMC8386270/ /pubmed/34483581 http://dx.doi.org/10.4103/njms.NJMS_242_20 Text en Copyright: © 2021 National Journal of Maxillofacial Surgery https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Sequeira, Joyce Sengupta, Shreya Mhatre, Bhupendra Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title | Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title_full | Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title_fullStr | Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title_full_unstemmed | Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title_short | Serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
title_sort | serum beta-2 microglobulin analysis in patients with oral squamous cell carcinoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386270/ https://www.ncbi.nlm.nih.gov/pubmed/34483581 http://dx.doi.org/10.4103/njms.NJMS_242_20 |
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