Cargando…

Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis

Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA....

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Chuankun, Gao, Shutao, Yuan, Xi, Shu, Zixing, Li, Song, Sun, Xuying, Xiao, Jun, Liu, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386564/
https://www.ncbi.nlm.nih.gov/pubmed/34339393
http://dx.doi.org/10.18632/aging.203349
_version_ 1783742286025195520
author Zhou, Chuankun
Gao, Shutao
Yuan, Xi
Shu, Zixing
Li, Song
Sun, Xuying
Xiao, Jun
Liu, Hui
author_facet Zhou, Chuankun
Gao, Shutao
Yuan, Xi
Shu, Zixing
Li, Song
Sun, Xuying
Xiao, Jun
Liu, Hui
author_sort Zhou, Chuankun
collection PubMed
description Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. Stratified analysis was conducted by ethnicity. In total, 66 case-control studies including 21681 cases and 23457 controls were obtained. For rs3087243 polymorphism, significant association was detected in Asians (A vs. G: OR=0.77, 95%CI=0.65-0.90, P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48-0.94, P=0.02) and Caucasians (A vs. G: OR=0.89, 95%CI=0.86-0.93, P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75-0.88, P<0.00001). For rs231775 polymorphism, significant association was observed in the overall (G vs. A: OR =1.16, 95%CI=1.08-1.25, P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50, P=0.0006), and in Asians (G vs. A: OR=1.27, 95%CI=1.10-1.47, P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01, P=0.0002), but not in Caucasians. However, there was no association between rs5742909 polymorphism and RA. This meta-analysis confirmed that rs3087243 and rs231775 polymorphism were associated with the risk of RA in both overall population and ethnic-specific analysis, but there was no association between rs5742909 polymorphism and RA risk.
format Online
Article
Text
id pubmed-8386564
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-83865642021-08-27 Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis Zhou, Chuankun Gao, Shutao Yuan, Xi Shu, Zixing Li, Song Sun, Xuying Xiao, Jun Liu, Hui Aging (Albany NY) Research Paper Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. Stratified analysis was conducted by ethnicity. In total, 66 case-control studies including 21681 cases and 23457 controls were obtained. For rs3087243 polymorphism, significant association was detected in Asians (A vs. G: OR=0.77, 95%CI=0.65-0.90, P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48-0.94, P=0.02) and Caucasians (A vs. G: OR=0.89, 95%CI=0.86-0.93, P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75-0.88, P<0.00001). For rs231775 polymorphism, significant association was observed in the overall (G vs. A: OR =1.16, 95%CI=1.08-1.25, P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50, P=0.0006), and in Asians (G vs. A: OR=1.27, 95%CI=1.10-1.47, P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01, P=0.0002), but not in Caucasians. However, there was no association between rs5742909 polymorphism and RA. This meta-analysis confirmed that rs3087243 and rs231775 polymorphism were associated with the risk of RA in both overall population and ethnic-specific analysis, but there was no association between rs5742909 polymorphism and RA risk. Impact Journals 2021-08-02 /pmc/articles/PMC8386564/ /pubmed/34339393 http://dx.doi.org/10.18632/aging.203349 Text en Copyright: © 2021 Zhou et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhou, Chuankun
Gao, Shutao
Yuan, Xi
Shu, Zixing
Li, Song
Sun, Xuying
Xiao, Jun
Liu, Hui
Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title_full Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title_fullStr Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title_full_unstemmed Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title_short Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
title_sort association between ctla-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386564/
https://www.ncbi.nlm.nih.gov/pubmed/34339393
http://dx.doi.org/10.18632/aging.203349
work_keys_str_mv AT zhouchuankun associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT gaoshutao associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT yuanxi associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT shuzixing associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT lisong associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT sunxuying associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT xiaojun associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis
AT liuhui associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis