Cargando…
Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA....
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386564/ https://www.ncbi.nlm.nih.gov/pubmed/34339393 http://dx.doi.org/10.18632/aging.203349 |
_version_ | 1783742286025195520 |
---|---|
author | Zhou, Chuankun Gao, Shutao Yuan, Xi Shu, Zixing Li, Song Sun, Xuying Xiao, Jun Liu, Hui |
author_facet | Zhou, Chuankun Gao, Shutao Yuan, Xi Shu, Zixing Li, Song Sun, Xuying Xiao, Jun Liu, Hui |
author_sort | Zhou, Chuankun |
collection | PubMed |
description | Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. Stratified analysis was conducted by ethnicity. In total, 66 case-control studies including 21681 cases and 23457 controls were obtained. For rs3087243 polymorphism, significant association was detected in Asians (A vs. G: OR=0.77, 95%CI=0.65-0.90, P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48-0.94, P=0.02) and Caucasians (A vs. G: OR=0.89, 95%CI=0.86-0.93, P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75-0.88, P<0.00001). For rs231775 polymorphism, significant association was observed in the overall (G vs. A: OR =1.16, 95%CI=1.08-1.25, P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50, P=0.0006), and in Asians (G vs. A: OR=1.27, 95%CI=1.10-1.47, P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01, P=0.0002), but not in Caucasians. However, there was no association between rs5742909 polymorphism and RA. This meta-analysis confirmed that rs3087243 and rs231775 polymorphism were associated with the risk of RA in both overall population and ethnic-specific analysis, but there was no association between rs5742909 polymorphism and RA risk. |
format | Online Article Text |
id | pubmed-8386564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Impact Journals |
record_format | MEDLINE/PubMed |
spelling | pubmed-83865642021-08-27 Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis Zhou, Chuankun Gao, Shutao Yuan, Xi Shu, Zixing Li, Song Sun, Xuying Xiao, Jun Liu, Hui Aging (Albany NY) Research Paper Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) gene polymorphisms may be involved in the risk of Rheumatoid arthritis (RA). However, evidence for the association remains controversial. Therefore, we performed a meta-analysis to confirm the relationship between CTLA-4 gene polymorphisms and RA. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of association. Stratified analysis was conducted by ethnicity. In total, 66 case-control studies including 21681 cases and 23457 controls were obtained. For rs3087243 polymorphism, significant association was detected in Asians (A vs. G: OR=0.77, 95%CI=0.65-0.90, P=0.001; AA vs. GG: OR=0.67, 95%CI=0.48-0.94, P=0.02) and Caucasians (A vs. G: OR=0.89, 95%CI=0.86-0.93, P<0.00001; AA vs. GG: OR=0.81, 95%CI=0.75-0.88, P<0.00001). For rs231775 polymorphism, significant association was observed in the overall (G vs. A: OR =1.16, 95%CI=1.08-1.25, P<0.0001; GG vs. AA: OR=1.29, 95%CI=1.12-1.50, P=0.0006), and in Asians (G vs. A: OR=1.27, 95%CI=1.10-1.47, P=0.001; GG vs. AA: OR=1.58, 95%CI=1.24-2.01, P=0.0002), but not in Caucasians. However, there was no association between rs5742909 polymorphism and RA. This meta-analysis confirmed that rs3087243 and rs231775 polymorphism were associated with the risk of RA in both overall population and ethnic-specific analysis, but there was no association between rs5742909 polymorphism and RA risk. Impact Journals 2021-08-02 /pmc/articles/PMC8386564/ /pubmed/34339393 http://dx.doi.org/10.18632/aging.203349 Text en Copyright: © 2021 Zhou et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Zhou, Chuankun Gao, Shutao Yuan, Xi Shu, Zixing Li, Song Sun, Xuying Xiao, Jun Liu, Hui Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title | Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title_full | Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title_fullStr | Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title_full_unstemmed | Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title_short | Association between CTLA-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
title_sort | association between ctla-4 gene polymorphism and risk of rheumatoid arthritis: a meta-analysis |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386564/ https://www.ncbi.nlm.nih.gov/pubmed/34339393 http://dx.doi.org/10.18632/aging.203349 |
work_keys_str_mv | AT zhouchuankun associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT gaoshutao associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT yuanxi associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT shuzixing associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT lisong associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT sunxuying associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT xiaojun associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis AT liuhui associationbetweenctla4genepolymorphismandriskofrheumatoidarthritisametaanalysis |