Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction

Monoclonal antibody (mAb) interchain disulfide bond reduction can cause a loss of function and negatively impact the therapeutic’s efficacy and safety. Disulfide bond reduction has been observed at various stages during the manufacturing process, including processing of the harvested material. The f...

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Detalles Bibliográficos
Autores principales: Park, Seo-Young, Egan, Susan, Cura, Anthony J., Aron, Kathryn L., Xu, Xuankuo, Zheng, Mengyuan, Borys, Michael, Ghose, Sanchayita, Li, Zhengjian, Lee, Kyongbum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386704/
https://www.ncbi.nlm.nih.gov/pubmed/34424810
http://dx.doi.org/10.1080/19420862.2021.1963094

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