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Pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs as possible candidates against neglected tropical diseases (NTDs): identification of hit compounds towards development of potential treatment of Leishmania donovani

A rational-based process was adopted for repurposing pyrrolidine-based 3-deoxysphingosylphosphorylcholine analogs bearing variable acyl chains, different stereochemical configuration and/or positional relationships. Structural features were highly influential on activity. Amongst, enantiomer 1e havi...

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Detalles Bibliográficos
Autores principales:	Hassan, Ahmed H. E., Phan, Trong-Nhat, Yoon, Seolmin, Lee, Cheol Jung, Jeon, Hye Rim, Kim, Seung-Hwan, No, Joo Hwan, Lee, Yong Sup
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386730/ https://www.ncbi.nlm.nih.gov/pubmed/34425714 http://dx.doi.org/10.1080/14756366.2021.1969385

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