Discovery of N-aryl sulphonamide-quinazoline derivatives as anti-gastric cancer agents in vitro and in vivo via activating the Hippo signalling pathway

Hippo signalling pathway plays a crucial role in tumorigenesis and cancer progression. In this work, we identified an N-aryl sulphonamide-quinazoline derivative, compound 9i as an anti-gastric cancer agent, which exhibited potent antiproliferative ability with IC(50) values of 0.36 μM (MGC-803 cells...

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Detalles Bibliográficos
Autores principales: Niu, Jin-Bo, Hua, Chun-Quan, Liu, Yuan, Yu, Guang-Xi, Yang, Jia-Jia, Li, Yin-Ru, Zhang, Yan-Bing, Qi, Ying-Qiu, Song, Jian, Jin, Cheng-Yun, Zhang, Sai-Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386742/
https://www.ncbi.nlm.nih.gov/pubmed/34425716
http://dx.doi.org/10.1080/14756366.2021.1958211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386742/
https://www.ncbi.nlm.nih.gov/pubmed/34425716
http://dx.doi.org/10.1080/14756366.2021.1958211

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