Cargando…
Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019
Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386799/ https://www.ncbi.nlm.nih.gov/pubmed/34424175 http://dx.doi.org/10.3201/eid2709.204843 |
_version_ | 1783742321886494720 |
---|---|
author | Gianecini, Ricardo Ariel Poklepovich, Tomas Golparian, Daniel Cuenca, Noelia Tuduri, Ezequiel Unemo, Magnus Campos, Josefina Galarza, Patricia |
author_facet | Gianecini, Ricardo Ariel Poklepovich, Tomas Golparian, Daniel Cuenca, Noelia Tuduri, Ezequiel Unemo, Magnus Campos, Josefina Galarza, Patricia |
author_sort | Gianecini, Ricardo Ariel |
collection | PubMed |
description | Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005–2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015–November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2–4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2–4 or >256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina. |
format | Online Article Text |
id | pubmed-8386799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-83867992021-09-04 Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 Gianecini, Ricardo Ariel Poklepovich, Tomas Golparian, Daniel Cuenca, Noelia Tuduri, Ezequiel Unemo, Magnus Campos, Josefina Galarza, Patricia Emerg Infect Dis Research Azithromycin-nonsusceptible Neisseria gonorrhoeae strains are an emerging global public health threat. During 2015–2018, the prevalence of azithromycin-nonsusceptible gonococcal infection increased significantly in Argentina. To investigate the genomic epidemiology and resistance mechanisms of these strains, we sequenced 96 nonsusceptible isolates collected in Argentina during 2005–2019. Phylogenomic analysis revealed 2 main clades, which were characterized by a limited geographic distribution, circulating during January 2015–November 2019. These clades included the internationally spreading multilocus sequence types (STs) 1580 and 9363. The ST1580 isolates, which had MICs of 2–4 μg/mL, had mutations in the 23S rRNA. The ST9363 isolates, which had MICs of 2–4 or >256 μg/mL, had mutations in the 23S rRNA, a mosaic mtr locus, or both. Identifying the geographic dissemination and characteristics of these predominant clones will guide public health policies to control the spread of azithromycin-nonsusceptible N. gonorrhoeae in Argentina. Centers for Disease Control and Prevention 2021-09 /pmc/articles/PMC8386799/ /pubmed/34424175 http://dx.doi.org/10.3201/eid2709.204843 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Gianecini, Ricardo Ariel Poklepovich, Tomas Golparian, Daniel Cuenca, Noelia Tuduri, Ezequiel Unemo, Magnus Campos, Josefina Galarza, Patricia Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title_full | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title_fullStr | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title_full_unstemmed | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title_short | Genomic Epidemiology of Azithromycin-Nonsusceptible Neisseria gonorrhoeae, Argentina, 2005–2019 |
title_sort | genomic epidemiology of azithromycin-nonsusceptible neisseria gonorrhoeae, argentina, 2005–2019 |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386799/ https://www.ncbi.nlm.nih.gov/pubmed/34424175 http://dx.doi.org/10.3201/eid2709.204843 |
work_keys_str_mv | AT gianeciniricardoariel genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT poklepovichtomas genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT golpariandaniel genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT cuencanoelia genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT tuduriezequiel genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT unemomagnus genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT camposjosefina genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT galarzapatricia genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 AT genomicepidemiologyofazithromycinnonsusceptibleneisseriagonorrhoeaeargentina20052019 |