Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged...

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Detalles Bibliográficos
Autores principales: Lynch, Maureen, Macori, Guerrino, Fanning, Séamus, O’Regan, Edel, Hunt, Eoin, O’Callaghan, Dermot, McCullagh, Brian, Jennings, Cormac, Fortune, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386806/
https://www.ncbi.nlm.nih.gov/pubmed/34161223
http://dx.doi.org/10.3201/eid2709.211159
Descripción
Sumario:We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.

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