Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged...

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Autores principales: Lynch, Maureen, Macori, Guerrino, Fanning, Séamus, O’Regan, Edel, Hunt, Eoin, O’Callaghan, Dermot, McCullagh, Brian, Jennings, Cormac, Fortune, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2021
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386806/
https://www.ncbi.nlm.nih.gov/pubmed/34161223
http://dx.doi.org/10.3201/eid2709.211159
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author Lynch, Maureen
Macori, Guerrino
Fanning, Séamus
O’Regan, Edel
Hunt, Eoin
O’Callaghan, Dermot
McCullagh, Brian
Jennings, Cormac
Fortune, Anne
author_facet Lynch, Maureen
Macori, Guerrino
Fanning, Séamus
O’Regan, Edel
Hunt, Eoin
O’Callaghan, Dermot
McCullagh, Brian
Jennings, Cormac
Fortune, Anne
author_sort Lynch, Maureen
collection PubMed
description We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
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spelling pubmed-83868062021-09-04 Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland Lynch, Maureen Macori, Guerrino Fanning, Séamus O’Regan, Edel Hunt, Eoin O’Callaghan, Dermot McCullagh, Brian Jennings, Cormac Fortune, Anne Emerg Infect Dis Research Letter We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants. Centers for Disease Control and Prevention 2021-09 /pmc/articles/PMC8386806/ /pubmed/34161223 http://dx.doi.org/10.3201/eid2709.211159 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Lynch, Maureen
Macori, Guerrino
Fanning, Séamus
O’Regan, Edel
Hunt, Eoin
O’Callaghan, Dermot
McCullagh, Brian
Jennings, Cormac
Fortune, Anne
Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title_full Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title_fullStr Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title_full_unstemmed Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title_short Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
title_sort genomic evolution of sars-cov-2 virus in immunocompromised patient, ireland
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386806/
https://www.ncbi.nlm.nih.gov/pubmed/34161223
http://dx.doi.org/10.3201/eid2709.211159
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