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Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence
BACKGROUND: Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial. METHODS: By collecting data both in the OHCA registry and in the dat...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386838/ https://www.ncbi.nlm.nih.gov/pubmed/34432840 http://dx.doi.org/10.1371/journal.pone.0256526 |
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author | Gentile, Francesca Romana Primi, Roberto Baldi, Enrico Compagnoni, Sara Mare, Claudio Contri, Enrico Reali, Francesca Bussi, Daniele Facchin, Fabio Currao, Alessia Bendotti, Sara Savastano, Simone |
author_facet | Gentile, Francesca Romana Primi, Roberto Baldi, Enrico Compagnoni, Sara Mare, Claudio Contri, Enrico Reali, Francesca Bussi, Daniele Facchin, Fabio Currao, Alessia Bendotti, Sara Savastano, Simone |
author_sort | Gentile, Francesca Romana |
collection | PubMed |
description | BACKGROUND: Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial. METHODS: By collecting data both in the OHCA registry and in the database of the regional agency for environmental protection (ARPA) of the Lombardy region, all medical OHCAs and the mean daily concentration of pollutants including fine particulate matter (PM(10), PM(2.5)), benzene (C(6)H(6)), carbon monoxide (CO), nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), and ozone (O(3)) were considered from January 1(st) to December 31(st), 2019 in the southern part of the Lombardy region (provinces of Pavia, Lodi, Cremona and Mantua; 7863 km2; about 1550000 inhabitants). Days were divided into high or low incidence of OHCA according to the median value. A Probit dose-response analysis and both uni- and multivariable logistic regression models were provided for each pollutant. RESULTS: The concentrations of all the pollutants were significantly higher in days with high incidence of OHCA except for O(3), which showed a significant countertrend. After correcting for temperature, a significant dose-response relationship was demonstrated for all the pollutants examined. All the pollutants were also strongly associated with high incidence of OHCA in multivariable analysis with correction for temperature, humidity, and day-to-day concentration changes. CONCLUSIONS: Our results clarify the link between pollutants and the acute risk of cardiac arrest suggesting the need of both improving the air quality and integrating pollution data in future models for the organization of emergency medical services. |
format | Online Article Text |
id | pubmed-8386838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-83868382021-08-26 Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence Gentile, Francesca Romana Primi, Roberto Baldi, Enrico Compagnoni, Sara Mare, Claudio Contri, Enrico Reali, Francesca Bussi, Daniele Facchin, Fabio Currao, Alessia Bendotti, Sara Savastano, Simone PLoS One Research Article BACKGROUND: Pollution has been suggested as a precipitating factor for cardiovascular diseases. However, data about the link between air pollution and the risk of out-of-hospital cardiac arrest (OHCA) are limited and controversial. METHODS: By collecting data both in the OHCA registry and in the database of the regional agency for environmental protection (ARPA) of the Lombardy region, all medical OHCAs and the mean daily concentration of pollutants including fine particulate matter (PM(10), PM(2.5)), benzene (C(6)H(6)), carbon monoxide (CO), nitrogen dioxide (NO(2)), sulphur dioxide (SO(2)), and ozone (O(3)) were considered from January 1(st) to December 31(st), 2019 in the southern part of the Lombardy region (provinces of Pavia, Lodi, Cremona and Mantua; 7863 km2; about 1550000 inhabitants). Days were divided into high or low incidence of OHCA according to the median value. A Probit dose-response analysis and both uni- and multivariable logistic regression models were provided for each pollutant. RESULTS: The concentrations of all the pollutants were significantly higher in days with high incidence of OHCA except for O(3), which showed a significant countertrend. After correcting for temperature, a significant dose-response relationship was demonstrated for all the pollutants examined. All the pollutants were also strongly associated with high incidence of OHCA in multivariable analysis with correction for temperature, humidity, and day-to-day concentration changes. CONCLUSIONS: Our results clarify the link between pollutants and the acute risk of cardiac arrest suggesting the need of both improving the air quality and integrating pollution data in future models for the organization of emergency medical services. Public Library of Science 2021-08-25 /pmc/articles/PMC8386838/ /pubmed/34432840 http://dx.doi.org/10.1371/journal.pone.0256526 Text en © 2021 Gentile et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gentile, Francesca Romana Primi, Roberto Baldi, Enrico Compagnoni, Sara Mare, Claudio Contri, Enrico Reali, Francesca Bussi, Daniele Facchin, Fabio Currao, Alessia Bendotti, Sara Savastano, Simone Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title | Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title_full | Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title_fullStr | Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title_full_unstemmed | Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title_short | Out-of-hospital cardiac arrest and ambient air pollution: A dose-effect relationship and an association with OHCA incidence |
title_sort | out-of-hospital cardiac arrest and ambient air pollution: a dose-effect relationship and an association with ohca incidence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386838/ https://www.ncbi.nlm.nih.gov/pubmed/34432840 http://dx.doi.org/10.1371/journal.pone.0256526 |
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