Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis

Autoimmune metaplastic atrophic gastritis is caused by immune-mediated destruction of gastric parietal cells. This leads to the absence of gastric acid production, which causes compensatory hyperplasia of gastric antral G-cells leading to hypergastrinemia. The excess gastrin binds to enterochromaffi...

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Detalles Bibliográficos
Autores principales: Brown, Patrick, Tetali, Bhavana, Suresh, Suraj, Varma, Adarsh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386912/
https://www.ncbi.nlm.nih.gov/pubmed/34476276
http://dx.doi.org/10.14309/crj.0000000000000649
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author Brown, Patrick
Tetali, Bhavana
Suresh, Suraj
Varma, Adarsh
author_facet Brown, Patrick
Tetali, Bhavana
Suresh, Suraj
Varma, Adarsh
author_sort Brown, Patrick
collection PubMed
description Autoimmune metaplastic atrophic gastritis is caused by immune-mediated destruction of gastric parietal cells. This leads to the absence of gastric acid production, which causes compensatory hyperplasia of gastric antral G-cells leading to hypergastrinemia. The excess gastrin binds to enterochromaffin-like cells causing hyperplasia, which may progress to dysplasia and rarely to gastric neuroendocrine tumors. We present a rare case of autoimmune metaplastic atrophic gastritis associated with G-cell hyperplasia showing the full developmental spectrum of enterochromaffin-like cell proliferation from hyperplasia to dysplasia to neuroendocrine tumor.
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spelling pubmed-83869122021-09-01 Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis Brown, Patrick Tetali, Bhavana Suresh, Suraj Varma, Adarsh ACG Case Rep J Case Report Autoimmune metaplastic atrophic gastritis is caused by immune-mediated destruction of gastric parietal cells. This leads to the absence of gastric acid production, which causes compensatory hyperplasia of gastric antral G-cells leading to hypergastrinemia. The excess gastrin binds to enterochromaffin-like cells causing hyperplasia, which may progress to dysplasia and rarely to gastric neuroendocrine tumors. We present a rare case of autoimmune metaplastic atrophic gastritis associated with G-cell hyperplasia showing the full developmental spectrum of enterochromaffin-like cell proliferation from hyperplasia to dysplasia to neuroendocrine tumor. Wolters Kluwer 2021-08-24 /pmc/articles/PMC8386912/ /pubmed/34476276 http://dx.doi.org/10.14309/crj.0000000000000649 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Brown, Patrick
Tetali, Bhavana
Suresh, Suraj
Varma, Adarsh
Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title_full Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title_fullStr Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title_full_unstemmed Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title_short Progression From Antral G-Cell Hyperplasia to Gastric Neuroendocrine Tumor in a Patient With Autoimmune Gastritis
title_sort progression from antral g-cell hyperplasia to gastric neuroendocrine tumor in a patient with autoimmune gastritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386912/
https://www.ncbi.nlm.nih.gov/pubmed/34476276
http://dx.doi.org/10.14309/crj.0000000000000649
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AT varmaadarsh progressionfromantralgcellhyperplasiatogastricneuroendocrinetumorinapatientwithautoimmunegastritis

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