Microglial dyshomeostasis drives perineuronal net and synaptic loss in a CSF1R(+/−) mouse model of ALSP, which can be rescued via CSF1R inhibitors

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is an autosomal dominant neurodegenerative disease caused by mutations in colony-stimulating factor 1 receptor (CSF1R). We sought to identify the role of microglial CSF1R haploinsufficiency in mediating pathogenesis. Using an i...

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Detalles Bibliográficos
Autores principales: Arreola, Miguel A., Soni, Neelakshi, Crapser, Joshua D., Hohsfield, Lindsay A., Elmore, Monica R. P., Matheos, Dina P., Wood, Marcelo A., Swarup, Vivek, Mortazavi, Ali, Green, Kim N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386924/
https://www.ncbi.nlm.nih.gov/pubmed/34433559
http://dx.doi.org/10.1126/sciadv.abg1601

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386924/
https://www.ncbi.nlm.nih.gov/pubmed/34433559
http://dx.doi.org/10.1126/sciadv.abg1601

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