Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals

The SLC15 family of proton-coupled solute carriers PepT1 and PepT2 play a central role in human physiology as the principal route for acquiring and retaining dietary nitrogen. A remarkable feature of the SLC15 family is their extreme substrate promiscuity, which has enabled the targeting of these tr...

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Detalles Bibliográficos
Autores principales: Parker, Joanne L., Deme, Justin C., Wu, Zhiyi, Kuteyi, Gabriel, Huo, Jiandong, Owens, Raymond J., Biggin, Philip C., Lea, Susan M., Newstead, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8386928/
https://www.ncbi.nlm.nih.gov/pubmed/34433568
http://dx.doi.org/10.1126/sciadv.abh3355

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