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Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk

BACKGROUND: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. METHODS: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG...

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Autores principales: Forster, Derek, Lin, Nan, Levens, Justin, Stone, Rachael, Berry, Scott, Durbin, Eric, Jennings, C. Darrell, DiPaola, Robert, Kolesar, Jill M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387089/
https://www.ncbi.nlm.nih.gov/pubmed/34454683
http://dx.doi.org/10.1016/j.ajic.2021.04.005
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author Forster, Derek
Lin, Nan
Levens, Justin
Stone, Rachael
Berry, Scott
Durbin, Eric
Jennings, C. Darrell
DiPaola, Robert
Kolesar, Jill M.
author_facet Forster, Derek
Lin, Nan
Levens, Justin
Stone, Rachael
Berry, Scott
Durbin, Eric
Jennings, C. Darrell
DiPaola, Robert
Kolesar, Jill M.
author_sort Forster, Derek
collection PubMed
description BACKGROUND: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. METHODS: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. RESULTS: The overall antibody positivity rate of HCW was 1.55% (5/322; 95% confidence interval: 0.65%-3.71%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8% (9/499; 95% confidence interval 0.94%-3.45%). CONCLUSIONS: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission.
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spelling pubmed-83870892021-08-26 Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk Forster, Derek Lin, Nan Levens, Justin Stone, Rachael Berry, Scott Durbin, Eric Jennings, C. Darrell DiPaola, Robert Kolesar, Jill M. Am J Infect Control Major Article BACKGROUND: The purpose of this study was to assess the occupational SARS-CoV-2 infection risk among health care workers (HCW) at University of Kentucky HealthCare (UKHC) by evaluating the prevalence of SARS-CoV-2 antibodies. METHODS: This is a prospective cohort study of HCW at UKHC. SARS-CoV-2 IgG antibody seropositivity was measured in a CLIA-certified laboratory utilizing the Abbott Architect SARS-CoV-2 IgG antibody assay. Demographics and work type were self-reported by study participants via an emailed survey. RESULTS: The overall antibody positivity rate of HCW was 1.55% (5/322; 95% confidence interval: 0.65%-3.71%) at cohort entry. There were no differences in antibody positivity between those that worked directly with SARS-CoV-2 infected patients and those that did not. The antibody rate of positivity of patients during the same time period was similar, 1.8% (9/499; 95% confidence interval 0.94%-3.45%). CONCLUSIONS: Antibody positivity was low and similar between HCW and patients tested during a similar time period. HCW positivity rates did not appear to be impacted by caring for known SARS-CoV-2 infected patients suggesting that appropriate use of personal protective equipment is effective in protecting individuals from transmission. Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. 2021-09 2021-08-26 /pmc/articles/PMC8387089/ /pubmed/34454683 http://dx.doi.org/10.1016/j.ajic.2021.04.005 Text en © 2021 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Major Article
Forster, Derek
Lin, Nan
Levens, Justin
Stone, Rachael
Berry, Scott
Durbin, Eric
Jennings, C. Darrell
DiPaola, Robert
Kolesar, Jill M.
Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title_full Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title_fullStr Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title_full_unstemmed Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title_short Prevalence of SARS-CoV-2 IgG antibodies in health care workers at a tertiary care academic medical center – An assessment of occupational infection risk
title_sort prevalence of sars-cov-2 igg antibodies in health care workers at a tertiary care academic medical center – an assessment of occupational infection risk
topic Major Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387089/
https://www.ncbi.nlm.nih.gov/pubmed/34454683
http://dx.doi.org/10.1016/j.ajic.2021.04.005
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