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Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations
SUMMARY: Vertebral fracture (VF) locations are bimodally distributed in the spine. The association between VF and bone attenuation (BA) measured on chest CT scans varied according to the location of VFs, indicating that other factors than only BA play a role in the bimodal distribution of VFs. INTRO...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer London
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387252/ https://www.ncbi.nlm.nih.gov/pubmed/33594489 http://dx.doi.org/10.1007/s00198-020-05719-z |
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author | Driessen, J.H.M. van Dort, M.J. Romme, E.A.P.M. Wouters, E.F.M. Smeenk, F.W.J.M. van Rietbergen, B. van den Bergh, J.P.W. Geusens, P. |
author_facet | Driessen, J.H.M. van Dort, M.J. Romme, E.A.P.M. Wouters, E.F.M. Smeenk, F.W.J.M. van Rietbergen, B. van den Bergh, J.P.W. Geusens, P. |
author_sort | Driessen, J.H.M. |
collection | PubMed |
description | SUMMARY: Vertebral fracture (VF) locations are bimodally distributed in the spine. The association between VF and bone attenuation (BA) measured on chest CT scans varied according to the location of VFs, indicating that other factors than only BA play a role in the bimodal distribution of VFs. INTRODUCTION: Vertebral fractures (VFs) are associated with low bone mineral density but are not equally distributed throughout the spine and occur most commonly at T7–T8 and T11–T12 (“cVFs”) and less commonly at T4–T6 and T9–T10 (“lcVF”). We aimed to determine whether associations between bone attenuation (BA) and VFs vary between subjects with cVFs only, with lcVFs only and with both cVFs and lcVFs. METHODS: Chest CT images of T4–T12 in 1237 smokers with and without COPD were analysed for prevalent VFs according to the method described by Genant (11,133 vertebrae). BA (expressed in Hounsfield units) was measured in all non-fractured vertebrae (available for 10,489 vertebrae). Linear regression was used to compare mean BA, and logistic regression was used to estimate the association of BA with prevalent VFs (adjusted for age and sex). RESULTS: On vertebral level, the proportion of cVFs was significantly higher than of lcVF (5.6% vs 2.0%). Compared to subjects without VFs, BA was 15% lower in subjects with cVFs (p < 0.0001), 25% lower in subjects with lcVFs (p < 0.0001) and lowest in subjects with cVFs and lcVFs (− 32%, p < 0.0001). The highest ORs for presence of VFs per − 1SD BA per vertebra were found in subjects with both cVFs and lcVFs (3.8 to 4.6). CONCLUSIONS: The association between VFs and BA differed according to VF location. ORs increased from subjects with cVFs to subjects with lcVFs and were highest in subjects with cVFs and lcVFs, indicating that other factors than only BA play a role in the bimodal VF distribution. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT00292552 |
format | Online Article Text |
id | pubmed-8387252 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer London |
record_format | MEDLINE/PubMed |
spelling | pubmed-83872522021-09-09 Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations Driessen, J.H.M. van Dort, M.J. Romme, E.A.P.M. Wouters, E.F.M. Smeenk, F.W.J.M. van Rietbergen, B. van den Bergh, J.P.W. Geusens, P. Osteoporos Int Original Article SUMMARY: Vertebral fracture (VF) locations are bimodally distributed in the spine. The association between VF and bone attenuation (BA) measured on chest CT scans varied according to the location of VFs, indicating that other factors than only BA play a role in the bimodal distribution of VFs. INTRODUCTION: Vertebral fractures (VFs) are associated with low bone mineral density but are not equally distributed throughout the spine and occur most commonly at T7–T8 and T11–T12 (“cVFs”) and less commonly at T4–T6 and T9–T10 (“lcVF”). We aimed to determine whether associations between bone attenuation (BA) and VFs vary between subjects with cVFs only, with lcVFs only and with both cVFs and lcVFs. METHODS: Chest CT images of T4–T12 in 1237 smokers with and without COPD were analysed for prevalent VFs according to the method described by Genant (11,133 vertebrae). BA (expressed in Hounsfield units) was measured in all non-fractured vertebrae (available for 10,489 vertebrae). Linear regression was used to compare mean BA, and logistic regression was used to estimate the association of BA with prevalent VFs (adjusted for age and sex). RESULTS: On vertebral level, the proportion of cVFs was significantly higher than of lcVF (5.6% vs 2.0%). Compared to subjects without VFs, BA was 15% lower in subjects with cVFs (p < 0.0001), 25% lower in subjects with lcVFs (p < 0.0001) and lowest in subjects with cVFs and lcVFs (− 32%, p < 0.0001). The highest ORs for presence of VFs per − 1SD BA per vertebra were found in subjects with both cVFs and lcVFs (3.8 to 4.6). CONCLUSIONS: The association between VFs and BA differed according to VF location. ORs increased from subjects with cVFs to subjects with lcVFs and were highest in subjects with cVFs and lcVFs, indicating that other factors than only BA play a role in the bimodal VF distribution. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT00292552 Springer London 2021-02-16 2021 /pmc/articles/PMC8387252/ /pubmed/33594489 http://dx.doi.org/10.1007/s00198-020-05719-z Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Original Article Driessen, J.H.M. van Dort, M.J. Romme, E.A.P.M. Wouters, E.F.M. Smeenk, F.W.J.M. van Rietbergen, B. van den Bergh, J.P.W. Geusens, P. Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title | Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title_full | Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title_fullStr | Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title_full_unstemmed | Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title_short | Associations between bone attenuation and prevalent vertebral fractures on chest CT scans differ with vertebral fracture locations |
title_sort | associations between bone attenuation and prevalent vertebral fractures on chest ct scans differ with vertebral fracture locations |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387252/ https://www.ncbi.nlm.nih.gov/pubmed/33594489 http://dx.doi.org/10.1007/s00198-020-05719-z |
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