Cargando…

The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis

OBJECTIVE: Increased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays an important role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) to the inflammation-LV mass relationship is unknown. In subjects with psorias...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Wunan, Teklu, Meron, Bui, Vy, Manyak, Grigory A., Kapoor, Promita, Dey, Amit K., Sorokin, Alexander V., Patel, Nidhi, Teague, Heather L., Playford, Martin P., Erb-Alvarez, Julie, Rodante, Justin A., Keel, Andrew, Shanbhag, Sujata M., Hsu, Li-Yueh, Bluemke, David A., Chen, Marcus Y., Carlsson, Marcus, Mehta, Nehal N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387288/
https://www.ncbi.nlm.nih.gov/pubmed/34611643
http://dx.doi.org/10.1016/j.ajpc.2021.100211
_version_ 1783742431510921216
author Zhou, Wunan
Teklu, Meron
Bui, Vy
Manyak, Grigory A.
Kapoor, Promita
Dey, Amit K.
Sorokin, Alexander V.
Patel, Nidhi
Teague, Heather L.
Playford, Martin P.
Erb-Alvarez, Julie
Rodante, Justin A.
Keel, Andrew
Shanbhag, Sujata M.
Hsu, Li-Yueh
Bluemke, David A.
Chen, Marcus Y.
Carlsson, Marcus
Mehta, Nehal N.
author_facet Zhou, Wunan
Teklu, Meron
Bui, Vy
Manyak, Grigory A.
Kapoor, Promita
Dey, Amit K.
Sorokin, Alexander V.
Patel, Nidhi
Teague, Heather L.
Playford, Martin P.
Erb-Alvarez, Julie
Rodante, Justin A.
Keel, Andrew
Shanbhag, Sujata M.
Hsu, Li-Yueh
Bluemke, David A.
Chen, Marcus Y.
Carlsson, Marcus
Mehta, Nehal N.
author_sort Zhou, Wunan
collection PubMed
description OBJECTIVE: Increased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays an important role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) to the inflammation-LV mass relationship is unknown. In subjects with psoriasis, a chronic inflammatory skin disease, we evaluated if systemic inflammation assessed by plasma glycoprotein A (GlycA) associated with LV mass measured on coronary CT angiography (CCTA). Additionally, we analyzed whether this relationship was mediated by early CAD assessed as noncalcified coronary burden (NCB). METHODS: We performed an observational longitudinal study of 213 subjects with psoriasis free of known cardiovascular disease, 189 of whom were followed over one year. All participants had GlycA measurements by nuclear magnetic resonance spectroscopy and LV mass and NCB quantified by CCTA. RESULTS: The cohort had a mean age of 50.3 (±12.9) years and 59% were male. There was moderate psoriasis severity and low cardiovascular risk. LV mass increased by GlycA tertiles [1st tertile:24.6 g/m(2.7)(3.8), 2nd tertile:25.5 g/m(2.7)(3.8), 3rd tertile:27.7 g/m(2.7)(5.5), p<0.001]. Both GlycA (β=0.24, p = 0.001) and NCB (β=0.50, p<0.001) associated with LV mass in models adjusted for age, sex, hypertension, hypertension therapy, lipid therapy, biologic therapy for psoriasis, waist:hip ratio, psoriasis disease duration and severity. In multivariable-adjusted mediation analyses, NCB accounted for 32% of the GlycA-LV mass relationship. Finally, over one year, change in NCB independently associated with change in LV mass (β=0.25, p = 0.002). CONCLUSIONS: Both systemic inflammation and coronary artery NCB were associated with LV mass beyond cardiovascular risk factors in psoriasis. Furthermore, a substantial proportion of the inflammatory-LV mass relationship was mediated by NCB. These findings underscore the possible contribution of early coronary artery disease to the relationship between systemic inflammation and LV mass.
format Online
Article
Text
id pubmed-8387288
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-83872882021-10-04 The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis Zhou, Wunan Teklu, Meron Bui, Vy Manyak, Grigory A. Kapoor, Promita Dey, Amit K. Sorokin, Alexander V. Patel, Nidhi Teague, Heather L. Playford, Martin P. Erb-Alvarez, Julie Rodante, Justin A. Keel, Andrew Shanbhag, Sujata M. Hsu, Li-Yueh Bluemke, David A. Chen, Marcus Y. Carlsson, Marcus Mehta, Nehal N. Am J Prev Cardiol Original Research Contribution OBJECTIVE: Increased left ventricular (LV) mass is an important precursor to heart failure. Inflammation plays an important role in increasing LV mass. However, the contribution of subclinical coronary artery disease (CAD) to the inflammation-LV mass relationship is unknown. In subjects with psoriasis, a chronic inflammatory skin disease, we evaluated if systemic inflammation assessed by plasma glycoprotein A (GlycA) associated with LV mass measured on coronary CT angiography (CCTA). Additionally, we analyzed whether this relationship was mediated by early CAD assessed as noncalcified coronary burden (NCB). METHODS: We performed an observational longitudinal study of 213 subjects with psoriasis free of known cardiovascular disease, 189 of whom were followed over one year. All participants had GlycA measurements by nuclear magnetic resonance spectroscopy and LV mass and NCB quantified by CCTA. RESULTS: The cohort had a mean age of 50.3 (±12.9) years and 59% were male. There was moderate psoriasis severity and low cardiovascular risk. LV mass increased by GlycA tertiles [1st tertile:24.6 g/m(2.7)(3.8), 2nd tertile:25.5 g/m(2.7)(3.8), 3rd tertile:27.7 g/m(2.7)(5.5), p<0.001]. Both GlycA (β=0.24, p = 0.001) and NCB (β=0.50, p<0.001) associated with LV mass in models adjusted for age, sex, hypertension, hypertension therapy, lipid therapy, biologic therapy for psoriasis, waist:hip ratio, psoriasis disease duration and severity. In multivariable-adjusted mediation analyses, NCB accounted for 32% of the GlycA-LV mass relationship. Finally, over one year, change in NCB independently associated with change in LV mass (β=0.25, p = 0.002). CONCLUSIONS: Both systemic inflammation and coronary artery NCB were associated with LV mass beyond cardiovascular risk factors in psoriasis. Furthermore, a substantial proportion of the inflammatory-LV mass relationship was mediated by NCB. These findings underscore the possible contribution of early coronary artery disease to the relationship between systemic inflammation and LV mass. Elsevier 2021-05-30 /pmc/articles/PMC8387288/ /pubmed/34611643 http://dx.doi.org/10.1016/j.ajpc.2021.100211 Text en Published by Elsevier B.V. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Contribution
Zhou, Wunan
Teklu, Meron
Bui, Vy
Manyak, Grigory A.
Kapoor, Promita
Dey, Amit K.
Sorokin, Alexander V.
Patel, Nidhi
Teague, Heather L.
Playford, Martin P.
Erb-Alvarez, Julie
Rodante, Justin A.
Keel, Andrew
Shanbhag, Sujata M.
Hsu, Li-Yueh
Bluemke, David A.
Chen, Marcus Y.
Carlsson, Marcus
Mehta, Nehal N.
The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title_full The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title_fullStr The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title_full_unstemmed The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title_short The relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
title_sort relationship between systemic inflammation and increased left ventricular mass is partly mediated by noncalcified coronary artery disease burden in psoriasis
topic Original Research Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387288/
https://www.ncbi.nlm.nih.gov/pubmed/34611643
http://dx.doi.org/10.1016/j.ajpc.2021.100211
work_keys_str_mv AT zhouwunan therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT teklumeron therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT buivy therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT manyakgrigorya therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT kapoorpromita therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT deyamitk therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT sorokinalexanderv therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT patelnidhi therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT teagueheatherl therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT playfordmartinp therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT erbalvarezjulie therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT rodantejustina therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT keelandrew therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT shanbhagsujatam therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT hsuliyueh therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT bluemkedavida therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT chenmarcusy therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT carlssonmarcus therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT mehtanehaln therelationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT zhouwunan relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT teklumeron relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT buivy relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT manyakgrigorya relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT kapoorpromita relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT deyamitk relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT sorokinalexanderv relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT patelnidhi relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT teagueheatherl relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT playfordmartinp relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT erbalvarezjulie relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT rodantejustina relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT keelandrew relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT shanbhagsujatam relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT hsuliyueh relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT bluemkedavida relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT chenmarcusy relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT carlssonmarcus relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis
AT mehtanehaln relationshipbetweensystemicinflammationandincreasedleftventricularmassispartlymediatedbynoncalcifiedcoronaryarterydiseaseburdeninpsoriasis