LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation

Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. The first lysosome targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent ma...

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Detalles Bibliográficos
Autores principales: Ahn, Green, Banik, Steven M., Miller, Caitlyn L., Riley, Nicholas M., Cochran, Jennifer R., Bertozzi, Carolyn R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387313/
https://www.ncbi.nlm.nih.gov/pubmed/33767387
http://dx.doi.org/10.1038/s41589-021-00770-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387313/
https://www.ncbi.nlm.nih.gov/pubmed/33767387
http://dx.doi.org/10.1038/s41589-021-00770-1

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