Current gene panels account for nearly all homologous recombination repair-associated multiple-case breast cancer families

It was hypothesized that variants in underexplored homologous recombination repair (HR) genes could explain unsolved multiple-case breast cancer (BC) families. We investigated HR deficiency (HRD)-associated mutational signatures and second hits in tumor DNA from familial BC cases. No candidates gene...

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Detalles Bibliográficos
Autores principales: Matis, Thibaut S., Zayed, Nadia, Labraki, Bouchra, de Ladurantaye, Manon, Matis, Théophane A., Camacho Valenzuela, José, Hamel, Nancy, Atayan, Adrienne, Rivera, Barbara, Tabach, Yuval, Tonin, Patricia N., Orthwein, Alexandre, Mes-Masson, Anne-Marie, El Haffaf, Zaki, Foulkes, William D., Polak, Paz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387362/
https://www.ncbi.nlm.nih.gov/pubmed/34433815
http://dx.doi.org/10.1038/s41523-021-00315-8

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