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Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks
A pandemic of Salmonella enterica serotype Enteritidis emerged in the 1980s due to contaminated poultry products. How Salmonella Enteritidis rapidly swept through continents remains a historical puzzle as the pathogen continues to cause outbreaks and poultry supply becomes globalized. We hypothesize...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387372/ https://www.ncbi.nlm.nih.gov/pubmed/34433807 http://dx.doi.org/10.1038/s41467-021-25319-7 |
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author | Li, Shaoting He, Yingshu Mann, David Ames Deng, Xiangyu |
author_facet | Li, Shaoting He, Yingshu Mann, David Ames Deng, Xiangyu |
author_sort | Li, Shaoting |
collection | PubMed |
description | A pandemic of Salmonella enterica serotype Enteritidis emerged in the 1980s due to contaminated poultry products. How Salmonella Enteritidis rapidly swept through continents remains a historical puzzle as the pathogen continues to cause outbreaks and poultry supply becomes globalized. We hypothesize that international trade of infected breeding stocks causes global spread of the pathogen. By integrating over 30,000 Salmonella Enteritidis genomes from 98 countries during 1949–2020 and international trade of live poultry from the 1980s to the late 2010s, we present multifaceted evidence that converges on a high likelihood, global scale, and extended protraction of Salmonella Enteritidis dissemination via centralized sourcing and international trade of breeding stocks. We discovered recent, genetically near-identical isolates from domestically raised poultry in North and South America. We obtained phylodynamic characteristics of global Salmonella Enteritidis populations that lend spatiotemporal support for its dispersal from centralized origins during the pandemic. We identified concordant patterns of international trade of breeding stocks and quantitatively established a driving role of the trade in the geographic dispersal of Salmonella Enteritidis, suggesting that the centralized origins were infected breeding stocks. Here we demonstrate the value of integrative and hypothesis-driven data mining in unravelling otherwise difficult-to-probe pathogen dissemination from hidden origins. |
format | Online Article Text |
id | pubmed-8387372 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-83873722021-09-22 Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks Li, Shaoting He, Yingshu Mann, David Ames Deng, Xiangyu Nat Commun Article A pandemic of Salmonella enterica serotype Enteritidis emerged in the 1980s due to contaminated poultry products. How Salmonella Enteritidis rapidly swept through continents remains a historical puzzle as the pathogen continues to cause outbreaks and poultry supply becomes globalized. We hypothesize that international trade of infected breeding stocks causes global spread of the pathogen. By integrating over 30,000 Salmonella Enteritidis genomes from 98 countries during 1949–2020 and international trade of live poultry from the 1980s to the late 2010s, we present multifaceted evidence that converges on a high likelihood, global scale, and extended protraction of Salmonella Enteritidis dissemination via centralized sourcing and international trade of breeding stocks. We discovered recent, genetically near-identical isolates from domestically raised poultry in North and South America. We obtained phylodynamic characteristics of global Salmonella Enteritidis populations that lend spatiotemporal support for its dispersal from centralized origins during the pandemic. We identified concordant patterns of international trade of breeding stocks and quantitatively established a driving role of the trade in the geographic dispersal of Salmonella Enteritidis, suggesting that the centralized origins were infected breeding stocks. Here we demonstrate the value of integrative and hypothesis-driven data mining in unravelling otherwise difficult-to-probe pathogen dissemination from hidden origins. Nature Publishing Group UK 2021-08-25 /pmc/articles/PMC8387372/ /pubmed/34433807 http://dx.doi.org/10.1038/s41467-021-25319-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Shaoting He, Yingshu Mann, David Ames Deng, Xiangyu Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title | Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title_full | Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title_fullStr | Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title_full_unstemmed | Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title_short | Global spread of Salmonella Enteritidis via centralized sourcing and international trade of poultry breeding stocks |
title_sort | global spread of salmonella enteritidis via centralized sourcing and international trade of poultry breeding stocks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387372/ https://www.ncbi.nlm.nih.gov/pubmed/34433807 http://dx.doi.org/10.1038/s41467-021-25319-7 |
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