Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy

Fragile X syndrome (FXS), a disorder of synaptic development and function, is the most prevalent genetic form of intellectual disability and autism spectrum disorder. FXS mouse models display clinically-relevant phenotypes, such as increased anxiety and hyperactivity. Despite their availability, so...

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Detalles Bibliográficos
Autores principales: Reyes, Samantha T., Deacon, Robert M. J., Guo, Scarlett G., Altimiras, Francisco J., Castillo, Jessa B., van der Wildt, Berend, Morales, Aimara P., Park, Jun Hyung, Klamer, Daniel, Rosenberg, Jarrett, Oberman, Lindsay M., Rebowe, Nell, Sprouse, Jeffrey, Missling, Christopher U., McCurdy, Christopher R., Cogram, Patricia, Kaufmann, Walter E., Chin, Frederick T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387417/
https://www.ncbi.nlm.nih.gov/pubmed/34433831
http://dx.doi.org/10.1038/s41598-021-94079-7

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